Jim and Buddy decide to follow their pal Tater-bug who left them for another job. No sooner do they arrive than Tater-bug gets shot in the back. Jim suspects Joe Weller but has no proof.
American federal agent Clark Stuart is on assignment in Santa Fe to draw up a trade agreement with the newly installed Mexican governor. Meanwhile, Walter Jamison leads a wagon train from Missouri, hoping to take advantage of the new agreement. Among Jamison's passenger are famed frontiersman Jim Bowie and a very youthful Kit Carson. The destinies of all these personalities intersect when villainous ex-governor DuPrey schemes to undermine the treaty and take over the New Mexico territory for his own vile purposes. Somewhere along the way, Davy Crockett joins the "good guys" in their efforts to thwart the despicable DuPrey.
In an effort to reach his wife's deathbed, Kirby is forced to kill a man in self-defense. He is arrested by Selwyn, a member of the North West Mounted Police, who allows him to say a last farewell to his wife. After visiting his wife's deathbed, Kirby eludes Selwyn and becomes a fugitive from the police. Each year he returns to visit his son and, during one of his sojourns, meets Margy, a little farmhouse servant who has run away from her life of drudgery.
As the Civil War begins, Ned Burton leaves his Southern love Agatha Warren and joins the Union army. He is later protected and saved from death by Agatha in spite of her loyalty to the South.
The Utah Kid eludes a sheriff's posse and takes refuge in Robber's Roost, a hideout for outlaws running from the law where he meets and falls for a waylaid school teacher.
Girl's father who is in sore financial straits because of a corporation man is aided by stranger who reveals that his father was ruined same way by the same person. When this man is found dead suspicion falls on girl's father but the employer of murdered man confesses.
The period is the 1840's and Greg Thurston is out to establish his own empire out of a large area of the west. He needs rifles to give to the Indians but Monte Hale breaks up his attack on the supply train. But when they get them by robbing the warehouse, Monte suspects Thuston who had the other key. He follows Thurston only to be caught by him just as Thurston launches his final big attack.
A young ranch hand hunts justice for his sister through the vast landscape of South Dakota. As he wrestles with what he is about to do, Cody crosses paths with a local county sheriff coming to terms with what she has already done.
The U.S. Army and the Indians sign a peace treaty. However, a group of surveyors trespass on the Indians' land and violate the treaty. The army refuses to listen to the Indians' complaints, and the surveyors are killed by the Indians. A vicious Indian war ensues, culminating in an Indian attack on an army fort.
Jimmy Hayes joins the Texas rangers. He causes much merriment by introducing to his new friends an ugly horned toad, around the neck of which he has tied a bright ribbon. He has named the horned toad "Muriel," and it is his constant companion, having a domicile within his flannel shirt.
Bat "No Limit" Carson, U.S. deputy marshal has to battle all types of varmints, including crooked dance hall proprietor "Con" Norton and his star entertainer, Fay La Cross. The booty is various gold shipments, and the beautiful heroine hails from the East.