When three drifters come into the possession of stolen gold they are imprisoned then sprung by a friend and tracked by the outlaw Jackson brothers, who originally stole the gold.
A widow hires an ex-gambler to retrieve gold bars from a sunken river boat in Colorado and discreetly return them to the Federal Mint, from where they had been stolen by her dead husband.
When half-breed Indian Yaqui Joe robs an Arizona bank, he is pursued by dogged lawman Lyedecker. Fleeing to Mexico, Joe is imprisoned by General Verdugo, who is waging a war against the Yaqui Indians. When Lyedecker attempts to intervene, he is thrown into prison as well. Working together, the two escape and take refuge in the hills, where Lyedecker meets beautiful Yaqui freedom fighter Sarita and begins to question his allegiances.
Gumercindo is a simple man who sees the daughter become pregnant of the son of its boss. Determined to demand that his grandson have a father, he joins neighbors to seek justice in his own way.
When the Indian Jimmyboy is accused of murder of a white man, he flees onto the ranch of Smith, who's well known for his tolerance for Indians, since he was raised by the old Indian Antoine. Smith helps Jimmyboy against the mean Sheriff and promises to speak for him in court, thus persuading him to surrender himself to the police.
A bandit kidnaps a Marshal who has seen a map showing a gold vein on Indian lands, but other groups are looking for it too, while the Apache try to keep the secret location undisturbed.
Fifteen-year-old Cav Rand purchases a racehorse and trains him into a winner, but a con artist is plotting to get the stallion away from the innocent Cav.
Geoffredo Scarciofolo (using the pseudonym "Jeff Cameron") is the famed gunfighter Sartana, who is offered a chance at amnesty from the $12,000 bounty on his head if he wipes out Benny Randal, his brother Baby Face, and an equally nasty sheriff.