A cowboy is wrongfully accused of murder. He winds up in Harlem, where he assumes the identity of a preacher-turned-gangster who looks like him. He infiltrates the gang to catch the men who framed him.
A western town is being overrun and ruled by a gang of outlaws led by Bart (John Merton). Former Ranger Tim (Tim McCoy) is called out of retirement and assigned to clean up the gang. He disguises himself as a Mexican bandit, joins the gang and works from within.
Ken and Happy, looking for their friend Cherokee, run into an outlaw gang led by Ritter who have been terrorizing the ranchers. Ken figures that one of the prominent citizens is the real boss and sets a trap to find him.
In his starring debut, Roy gets elected to Congress in order to bring water to the ranchers in his district. In Washington, he learns he needs the backing of a key congressman and gets that man to go west for an inspection trip. When the congressman is initially unimpressed, Roy gets the inspection party stranded without water to show the true conditions.
When Tex is brought in to fight in a range war between the cowmen and the nesters, he meets his old outlaw boss Lassiter. He learns Lassiter is behind the feud when Lassiter asks him to join up with his gang. Tex refuses and instead sets out to stop the feud but no one will believe him that Lassiter is responsible.
It's 1861 and Buck gets the business men of Sacramento to establish the Pony express. Hawley runs the stage line over the same route and has the U. S. mail contract. When it looks like the Pony Express will be awarded the mail contract, he gives guns to the Indians and has them attack both the riders and the stations.
Saunders with his Cattlemen's Protective Agency is running roughshod over the ranchers. Lawyer Larry Kimball is fighting him but he needs a rancher that will stand up with him against Saunders. He finds him when Lou Gehrig retires from baseball to take up ranching. Lou expects to relax on his ranch but quickly joins Larry in the fight.
Tip Douglas is sent after cattle rustlers, the same rustlers that murdered his father. Posing as a notorious outlaw, he is able to join the gang. Learning that the gang's boss Thorn Evans killed his father, he and sidekick Pepper set a trap when he learns of their next raid.
Bob arrives looking for the killer of his uncle. When the Sheriff chases him and his partner Rusty, Reno thinks they are the men he is looking for and takes them into his gang. There Bob finds his uncle's gun and knows he has found the right gang. However he realizes the gang has an unknown leader and he sets out to find him.
The strip is being opened to settlers and as everyone heads for the starting line, Thad and his outlaw gang are ready. Learning Rankin has a treasure map, Thad steals it. When Breezy attempts to recover the map he is captured by Thad. With Breezy tied up, Thad heads out to claim the treasure plot.
The Three Mesquiteers are forced to track down a train robbery ring after some of the gang hijack their truck for a getaway and the police conclude they are part of the gang, an identification which is just fine with the gang's nameless chief.
Regan is passing off counterfeit money at rodeos betting on his man Denby. When Tex appears and wins all the events, Regan has him accused of murder. As Tex looks for the counterfeiters, his pals Stubby and Pee Wee keep the Sheriff off his trail.
Just after Carson's gang murder members of a wagon train, Rusty and Clem come along and are arrested. Knowing they are innocent Judge Coleman breaks them out and sends them after Carson. They join Carson's gang to learn of their next raid but the Marshal arrests them for the wagon train murders.
Hopalong Cassidy, boss of the Bar 20 ranch in Texas, rides down the Camino Real in the New Mexico cattle country near Alamogordo, in response to an urgent message from his lifelong sweetheart, Nora Blake, who is in serious trouble. Before he and his saddlemates, "Lucky" Jenkins and "Pappy", can reach her ranch, they are stopped by Clay Allison, a cattle-rustler who is in almost complete control of the district, and wants to extend his holdings by seizing Nora's cattle and driving her out. Seeing Cassidy as a menace to his plans, he has him arrested on a trumped-up charge. Cassidy and his pals shoot their way out of the trouble and reach Nora;s ranch where they learn that Allison's henchmen have murdered her foreman, Tom Dillon, and Allison has sent for a crew of outlaws on the Texas border.
Tom Keene, formerly George Duryea and latterly Richard Powers, made his final starring appearance in the Monogram western The Painted Trail. Keene is cast as a former federal agent who is drawn out of retirement to stem the activities of smugglers Boss (Leroy Mason) and Driscoll (Walter Long). Disguising himself as an outlaw, our hero gains the confidence of the two desperadoes, only to be found out at the least appropriate time. Rest assured that Keene saves the day and manages to march ingenue Ann (Eleanore Stewart) to the altar.