Government agent Gordon, working undercover, is investigating a cattleman sheepman war. The Culprit is Horton and when Horton kills Parker he frames Gordon. His identity revealed, the Sheriff lets Gordon escape to go after the real killer.
Rocky Rhodes returns to find his father dead and his best friend Joe accused of the murder. The culprit is Murtch who now lets Joe break jail and then has him shot escaping. When Rocky starts to interfere with Murtch's plans, he has Rocky framed for murder. Rocky now has to prove Murtch is guilty while escaping the law.
An Easterner Inherits a cattle ranch, only to discover that thousands of cattle have been stolen. He secretly signs on as a hired hand at his own ranch to discover who's stealing them.
A wagon train heads west from Independence, Mo., along the Oregon Trail, led by proud cowboy Clint Belmet. On board are feisty young widow Nancy Wellington and her toddler, Sonny, as well as the older Abby Masters, who begins a romance with scout Jim Burch. Along the way, the wagon train battles Indians led by Kenneth Murdock, a trapper who doesn't welcome competition for Oregon's lucrative fur trade. Wagon Wheels is a 1934 remake of 1931's Fighting Caravans, using stock footage from the original.
Sheriff Ed Dawson (Franklyn Farnum)asks Texas Rangers Wally Wallace (Hal Taliaferro) and Bill (Al Hoxie), to go into an outlaw stronghold, where his daughter Ann (Dorothy Crittin)is being held prisoner, and capture the gang led by Larkin (Yakima Canutt). But Wally's identity is revealed and they are taken prisoner.
Cattlemen Protective Agent Reb Russell arrives to try and stop the cattle rustling. He gains a friend when he saves Jack Thorn from Lenahan and his men. They hire on at the Lund ranch and when her cattle are rustled and she is kidnaped they follow the trail, It's Lenahan and his gang and Reb soon finds himself a prisoner.
Lawyer Creech is after the ranch of the dying Cartwright. First he brings in Cahill to pose as the only living relative. Then when the Tonto Kid finds platinum on the ranch, Creech frames him for murder.
Dyer is buying ranches and then retrieving his check by having his gang kill the owner. Bob Worth arrives just as Buck Morton is killed and gets blamed for the murder. Fleeing from the Sheriff, Bob teams up with the Mexican outlaw Golinda. Having seen Dyer pay off his men, he has a plan to trap him and Golinda is just the man he needs to make it work.
"Red" Davison(Buck Jones), the sheriff of Sun Dog, sacrifices his job and his good name to save his best friend, "Silent" Slade from the hangman's noose, following a framed-up court decision which sentences Slade to hang for the murder of "Scotty McKee (J.P. McGowan). Davidson allows Slade to escape from jail and follows him to aid him in proving his innocence.
The owner of a stagecoach line is about to lose his mail contract after 30 years because he's been underbid. His competitor is actually a crook who's planning to hijack the stagecoach and rob the mail--and, for good measure, have a go at his rival's pretty young daughter.
Jerry Hixon's ranch is being besieged by raiders so Ben sends for his friend Bud. When Bud arrives and finds that the outlaw Texarkana Pete has been captured, he buys Pete's clothes and posing as Pete joins the outlaw gang. But he is quickly in trouble when his masquerade is exposed.
Accused of a murder he did not commit, Ken leaves the country. Three years later Evans finds him in the jungle. When Evans dies, Ken seeing the resemblance, assumes his identity and returns to clear his name.
Reed breaks up the first attempted gold robbery. When the outlaws next attempt is successful, Reed is jailed as the suspect. Escaping from jail, he knows who to look for.
Bandits lead by Matt the Mute enter a bar and kill multiple people. Randy Bowers comes to town and is framed by Matt the Mute, who is working with the sheriff (who doesn't know Matt is really a criminal). Randy escapes with the help of the niece of the dead owner of the bar. Bowers ends up running from the sheriff, and ends up in the cave in which the bandits have their hide-out…