Among the tall trees and mountains of the Far West, a father, son and daughter dwell peacefully in their mountain cabin, close to nature, seldom hearing of the great restless world outside, happy in their isolation. Jack, the son, visiting town on business, is tempted into a gambling saloon and takes part in a game of cards. Dalton, a gambler, undertakes to fleece the boy. The result is a fight in which Dalton is shot, and Jack becomes a fugitive.
Road Agents begins as a pair of outlaws prepares to rob a stagecoach. Donning masks and brandishing six-guns, the bad guys relieve the passengers of their valuables and also make off with a box full of payroll money. As the sheriff organizes a posse, the bandits are seen dividing their loot. The greedier of the two crooks beats up his partner and absconds with their ill-gotten gains. The other bandit, thirsting for revenge, joins the sheriff's posse to track down his former chum.
A gang of outlaws are planning a bank robbery. After making preparations, they commit the robbery and make their escape amidst a sharp exchange of bullets. They return to their meeting place, and then hurriedly continue onwards, with lawmen close behind them.
A sheriff apprehends a bank robber and recovers the money. On the way back to town, the sheriff loses the recovered money in a crooked card game. The bank robber helps him recover it.
In a saloon in a Mexican border town, a group of cowboys, including a Mexican named Pedro, play poker. One man is discovered cheating, and is shot dead by Pedro, who is wounded as he attempts to escape. Pedro is followed home by the local sheriff, who proves the next victim of Pedro's quick temper and pistol. Pedro's wife, Juanita, is thrown into jail, but he manages to break her out. They head for the border, unaware that a posse is waiting for them.
In the 1849 American West, seductive outlaw Jack Morgan falls in love with Mollie, an innkeeper's daughter, already coveted by stagecoach driver Dick. After robbing Dick's stagecoach, Jack is chased by a posse of horsemen. Wounded, he finds refuge with Mollie, who hides and nurses him back to health. Hunted to a burning barn, Jack attempts to escape but is shot dead by Dick. Mollie finds him dying in her arms. Between romance, betrayal, and pursuit, the film intensely blends drama and adventure.
A very young girl goes to deliver lunch to the cowboys who have stayed behind on the plains. She climbs into a wagon. Along the way, the wagon is spotted by a man on horseback. The girl arrives and kisses her father, to whom she gives the lunch. Eventually, the child is kidnapped, and a ransom of 25,000 pounds is demanded. A ten-year-old boy offers to go and try to save the girl.
As a result of a stagecoach hold-up and other crimes, Buck Brady has become known locally as the "King of Bandits". The sheriff posts a $1000 reward for Brady, dead or alive. Soon a full-scale effort is underway to capture the bandit king.
As a young couple are courting, they are rudely interrupted and split up. The man is seized and is turned over to a gang of toughs who want to hang him. Though she is greatly outnumbered, the young woman wastes no time in making a determined effort to rescue him.
At dawn, two cowboys set out to scout ahead; as soon as they are on the trail of a herd of wild horses, they attempt to surround them and drive them back. A rapid stamping alerts their companions, who prepare the lassos; the ropes whistle, wind around the necks of the panicked beasts, which take a few more steps then, strangled and panting, are brought back captive. In the evening, they camp. Large fires are lit around which men and beasts settle down to sleep, not without a good guard being kept in the surrounding area. Meanwhile, the Apaches creep under cover of night to the American camp and succeed in seizing the captured beasts. Following this abduction, a frantic pursuit begins across the vast solitude of the Far West.
A train traveling through the Rockies is held up and boarded by two thugs. They rob the wealthy occupants at gunpoint and then make their getaway by handcar. From there, they hijack a horsecart on a road running parallel to the tracks. Will justice prevail in the end?