The film's storyline involves five survivors, one woman and four men, of an atomic bomb disaster. The five come together at a remote, isolated hillside house, where they try to figure out how to survive.
A team composed of an aerospace scientist, an ex-Air Force general, and an industrialist conceives an ambitious plan to land Americans on the moon. From their base in the Mojave Desert, they construct and successfully launch a spacecraft named "Luna" that contains a cargo of four astronauts. But a critical miscalculation of needed power to escape the moon's gravitational pull may put the astronauts' lives in danger.
Astronauts blast off to explore the moon on Rocketship X-M or "Rocketship eXploration Moon". A spacecraft malfunction and some fuel miscalculations cause them to end up landing on Mars. On Mars, evidence of a once powerful civilization is found. The scientists determined that an atomic war destroyed most of the Martians. Those that survived reverted to a caveman like existence.
The CIA sends playboy Mike Trent to Alaska with agent Vee Langley, posing as his "nurse," to investigate flying saucer sightings. At first, installed in a hunting lodge, the two play in the wilderness. But then they sight a saucer. Investigating, our heroes clash with an inept gang of Soviet spies, also after the saucer secret.
A scientist working on cures for rare afflictions, such as a bone softening agent made from molds to allow him to correct the spinal deformity of his nurse, finds the physical causes of lycanthropy in wolf-man Larry Talbot and of vampirism in Count Dracula, but himself becomes afflicted with homicidal madness while exchanging blood with Dracula.
Deranged scientist, Gustav Niemann, escapes from prison and overtakes the director of a traveling chamber of horrors, soon reviving the infamous Count Dracula, the frozen Frankenstein Monster, and the Wolf Man.
A fugitive, dangerous madman reaches an English village where he confronts his former partner who left him for dead in the jungle after their discovery of a diamond mine. When the former partner also claims to have since lost the mine and all its wealth, which he took all for himself, and though the partner is still living in a state of luxury , the madman takes up an offer from a crazed scientist to make him invisible, something the scientist has already done with experimental animals, so that he can take revenge.
Paula, the ape woman, has survived the ending of CAPTIVE WILD WOMAN and is running around a creepy old sanitarium run by the kindly Dr. Fletcher, reverting to her true gorilla form every once in a while to kill somebody.
A university chemistry professor experiments with an ancient Mayan gas on a medical student, turning the would-be surgeon into a murdering ghoul as part of a plan to steal his lover.
Grave robbers open the grave of the wolf man and awaken him. He doesn't like the idea of being immortal and killing people when the moon is full so tries to find Dr. Frankenstein, in the hopes that the doctor can cure him. Dr. Frankenstein has died; however, his monster is found.
Frankenstein's unscrupulous colleague, Dr. Bohmer, plans to transplant Ygor's brain so he can rule the world using the monster's body, but the plan goes sour when he turns malevolent and goes on a rampage.