In 1927, a Kansas City, Missouri cornet player and his band perform nightly at a seedy speakeasy until a racketeer tries to extort them in exchange for protection.
Three convicts escape from prison on Devil's Island just before Christmas and arrive at a nearby French colonial town. They go to the store of the Ducotels, the only store that gives supplies on credit. They initially intend to take advantage of them but have a change of heart after they find the family is in financial troubles.
Special investigator Duke Martin is in London to investigate the authenticity of a rare postage stamp called the Barbados Overplate. Someone is willing to commit murder to get his or her hands on the stamp, which puts a crimp in Duke's efforts to romance every beautiful woman he meets.
Richard Dadier is a teacher at North Manual High School, an inner-city school where many of the pupils frequently engage in anti-social behavior. Dadier makes various attempts to engage the students' interest in education, challenging both the school staff and the pupils. He is subjected to violence as well as duplicitous schemes.
Mr. Dean's body is found face down in the fireplace, burned beyond recognition. Nightclub-singer Eden Lane is convicted of the crime. She is escorted to prison by one of the arresting detectives when she convinces him that she just spotted the murderer outside their train.
One-armed war veteran John J. Macreedy steps off a train at the sleepy little town of Black Rock. Once there, he begins to unravel a web of lies, secrecy, and murder.
The tranquility of a small town is marred only by sheriff Tod Shaw's unsuccessful courtship of widow Ellen Benson, a pacifist who can't abide guns and those who use them. But violence descends on Ellen's household willy-nilly when the U.S. President passes through town... and slightly psycho hired assassin John Baron finds the Benson home ideal for an ambush.
Terry Malloy is a kindhearted dockworker, and former boxer, who is tricked by his corrupt bosses into leading his friend to death. After falling in love, he tries to leave the waterfront and expose his employers.
An ex-tennis pro carries out a plot to have his wealthy wife murdered after discovering she is having an affair, and assumes she will soon leave him for the other man anyway.
While in London trying to nab several fugitives who stole a million dollars from a U.S. Treasury vault, American federal agent Dennison (Dennis O'Keefe) assists Scotland Yard Insp. McClaren (Philip Friend) in his search for a missing atomic scientist (Paul Hardtmuth). The detective duo discovers that the key to solving both cases may rest with the scientist's daughter (Margaret Sheridan) and her fascinating diamond.
Bank teller Mike Donovan (Barry Sullivan) takes the first step on the road to Perdition when he fails to report a $49,000 shortage. Accused of theft, Donovan is fired from his job. He is then prevented from finding other employment by Javert-like insurance investigator Gus Slavin (Charles McGraw). Despite many setbacks, Donovan attempts to clear his muddied name.
When several women are found mutilated and murdered, the Paris police are baffled as to who the killer may be. All evidence points to Dupin, but soon it becomes apparent that it is someone (or something) stronger and deadlier than a human.