After his wife dies in childbirth, a doctor settles down in the small Oklahoma town of Cherokee Wells to raise his newborn daughter. Unfortunately, not all the citizens there are hospitable, especially when the doctor hires a pretty Indian teenager as his child's nanny.
In Medicine Bend, a crooked businessman has the town mayor and sheriff in his pocket while his henchmen raid the wagon trains passing through the region.
Back home in Texas following the Civil War, former Confederate officer Chad Morgan (Alan Ladd) leads a cattle drive to Missouri, assuring fellow ranchers that their stock will bring $10 a head at auction. Instead, ruthless cattle baron Brog (Anthony Caruso) has scared off all competition and offers much less.
The pioneering trail to Oregon was littered with constant danger. Yet, the hope of the "promised land" keeps American families westward bound despite overwhelming odds. A calm, clear-thinking pioneer attempts to lead a wagon train through territory occupied by Pawnees and Sioux. Along the way, the hardy settlers face horse thieves, kidnappers, and unpredictable Indian attacks in their push to establish a new life in the rugged West.
Lizzie Curry is on the verge of becoming a hopeless old maid. Her wit and intelligence and skills as a homemaker can't make up for the fact that she's just plain plain! Even the town sheriff, File, for whom she harbors a secrect yen, won't take a chance --- until the town suffers a drought and into the lives of Lizzie and her brothers and father comes one Bill Starbuck ... profession: Rainmaker!
At the end of the Civil War, a Confederate team is ordered to rob a Union payroll train but the war ends leaving these men with their Union loot, until the Feds come looking for it.
Wealthy rancher Bick Benedict and dirt-poor cowboy Jett Rink both woo Leslie Lynnton, a beautiful young woman from Maryland who is new to Texas. She marries Benedict, but she is shocked by the racial bigotry of the White Texans against the local people of Mexican descent. Rink discovers oil on a small plot of land, and while he uses his vast, new wealth to buy all the land surrounding the Benedict ranch, the Benedict's disagreement over prejudice fuels conflict that runs across generations.
Don Pablo Salazar steals a fortune in jewels from an Indian tribe and an Aztec medicine man puts a curse on the jewels until they are returned. Years later, an American insurance man promises to deliver the Salazar fortune to the rightful heir...
After he's continually harrassed and bullied by his town's citizens, the orphaned teenage son of a notorious gunslinger takes flight and joins a gang of youthful outlaws.
Rich momma's boy Wade Kingsley Jr. an Eastern dude, tries to follow in his murdered father's footsteps by returning to the West to partner up with Slim Moseley Jr.,the son of his father's former partner. Wade overcomes Slim's initial reluctance to accept him by using his fortune to buy a prize cow and new car to help Slim in his job as foreman on the Kingsley family ranch, currently under siege by a gang of outlaws called "masked raiders." Wade generously tries to pay off the ranch's mortgage with $15,000 of his own money, but unfortunately neither "pardner" realizes that respected banker Dan Hollis, the son of their fathers' murderer, is the leader of the gang.
Davy Crockett and his sidekick Georgie compete against boastful Mike Fink ("King of the River") in a boat race to New Orleans. Later, Davy and Georgie, allied with Fink, battle a group of river pirates trying to pass themselves off as Native Americans.
Whenever it becomes known how good he is with guns, ex-gunman George and his wife Dora have to flee the town, in fear of all the gunmen who might want to challenge him. Unfortunately he again spills his secret when he's drunk. All citizens swear to keep his secret and support him to give up his guns forever -- but a boy tells the story to a gang of wanted criminals. Their leader threatens to burn down the whole town, if he doesn't duel him.