On the outskirts of town, the hard-nosed Vienna owns a saloon frequented by the undesirables of the region, including Dancin' Kid and his gang. Another patron of Vienna's establishment is Johnny Guitar, a former gunslinger and her lover. When a heist is pulled in town that results in a man's death, Emma Small, Vienna's rival, rallies the townsfolk to take revenge on Vienna's saloon – even without proof of her wrongdoing.
Joe Branch, reputed to be the son of Jesse James, comes riding into Coffeyville Kansas, looking for proof one way or the other regarding the question of who his father was.
Brady Sutton returns from three years in prison and tries to go straight. One a member of the Butch Cassidy gang, he is still suspected of being cahoots with them. When Cassidy and his men rob the bank, he is blamed. Escaping from the townspeople, he once again joins up with Cassidy to wait for a chance to help bring him in.
During the Klondike Gold Rush, a misanthropic cattle driver and his talkative elderly partner run afoul of the law in Alaska and are forced to work for a saloon owner to take her supplies into a newly booming but lawless Candian town.
A spirited cast kicks up its heels in a lively musical spoof of cowboy films crammed with spur-jangling tunes by Jay Livingstone and Ray Evans and decked out with colorfully stylized, Oscar.-nominated sets. Rosemary Clooney heads up the high-kicking, red-gartered girls of the Red Dog Saloon. They can-can. but she won't-won't unless Jason (Jack Carson) asks her to get hitched. Guy Mitchell and Gene Barry are gun-totin' polecats who think they've got a feud to settle. And Frank Faylen and Buddy Ebsen are among the folks who hope the gunslingers get itchy fingered - so they can hold a town barbecue during the funeral!
A Confederate officer travels to a wild Mexican border town to buy guns, aiming to keep up the fight against the Yankees - but who can he trust in this lawless place?
Jim Harvey is hired to guard a small wagon train as it makes its way west. The train is attacked by Indians and Harvey, hoping to persuade Aguila, the chief, to call off the attack due to Harvey's having saved his son's life, leaves the train to negotiate. He is captured and the rest of the train is wiped out except for two sisters. Escaping and showing up in town later, Harvey is nearly hanged as a deserter, but gets away. Eventually caught by the sheriff and his posse, they are attacked by Indians. This time the Indians are defeated and Aguila, captured and dying, reveals the identity of the white man who engineered the initial attack on the wagon train, just as the perpetrator rides up behind them.
Sharpshooter Calamity Jane takes it upon herself to recruit a famous actress and bring her back to the local saloon, but jealousy soon gets in the way.
After a stagecoach holdup, Frank Slayton's notorious gang leave Ben Warren for dead and head off with his fiancée. Warren follows, and although none of the townspeople he comes across are prepared to help, he recruits two others who have sworn revenge on the ruthless Slayton.
Wes Anderson (Fred MacMurray) is caught cattle rustling and promptly jailed. The public is outraged, but, since Wes always worked at night, they don't know what he looks like. Still, they break into the prison and lynch a hobo they think is Wes, while the actual culprit sneaks off to see his old flame, Rela (Barbara Stanwyck), who has recently taken up with his straitlaced brother, Tom (William Ching). But Tom is envious of his outlaw brother, and he decides to join Wes in a life of crime.