The story starts following an incident: a young girl jumps from the top of a building. The image provokes a certain dread, as the girl appears to have been a corpse even before she jumped. The case is dismissed, yet more and more of these suicides occur, and all from the same building. Thus began the rumour, that a ghost inhabited the rooftop of the building.
Black Jack is a master surgeon who possesses impeccable skills, enabling him to perform operations that are impossible for even the finest surgeons. He now is faced with his most difficult task to date and must challenge the limits of medical science...before it's too late!
Giovanni currently lives a dreary life of near non-stop work. At school, his peers ridicule him incessantly, and his employer at work is distant and cold. As his isolation from society becomes unbearable, he suddenly finds himself on a train heading far away from his miserable home. Accompanied by Campanella, an acquaintance from school, Giovanni embarks on a journey that will define the rest of his life.