Two young clerks in a department store meet and fall in love during a seaside vacation in Maine, but part as strangers because, unknown to each other, both had been masquerading as upper-class 'swells', just to see how the better half lives.
Ojo and Unc Nunkie are out of food, so they decide to journey to the Emerald City where they will never starve. Along the way, they meet Mewel, a waif and stray (mule) who leads them to Dr. Pipt, who has been stirring the powder of life for nine years. Ojo adds plenty of brains to Margolotte's Patchwork servant before she is brought to life with the powder. When Scraps does come to life, she accidentally knocks the liquid of petrifaction upon Unc Nunkie, Margolotte, and Danx (daughter Jesseva's boyfriend). So all go on separate journeys to find the ingredients to the antidote.
Lillian Travers, a New York heiress, pops down to Florida to surprise her fiancé, Fred Cassadene, the house doctor at a prominent Saint Augustine hotel. The surprise, however, is Lillian's when she finds Fred in a series of compromising situations with a certain wealthy widow staying there. When she can take no more, Lillian discovers a box forgotten at an old curiosity shop in which lies a hundred-year-old secret: a vial of four rare and exotic African seeds that promises to transform whoever swallows one from a woman to a man or vice versa.