A pathologist experiments with a deaf-mute woman who is unable to scream to prove that humans die of fright due to an organism he names The Tingler that lives within each person on the spinal cord and is suppressed only when people scream when scared.
A backwoods game warden and a local doctor discover that giant leeches are responsible for disappearances and deaths in a local swamp, but the local police don't believe them.
Trapped on a remote island by a hurricane, a group discover a doctor has been experimenting on creating half sized humans. Unfortunately, his experiments have also created giant shrews, who when they have run out of small animals to eat, turn on the humans.
Frederick Loren invites five strangers to the party of a lifetime and offers each of them $10,000 if they can stay the night in the reportedly haunted house. Armed with a gun for protection, each guest arrives in a hearse and will either leave in it much richer…Or dead.
A college paleontology professor acquires a newly discovered specimen of a coelacanth, but while examining it, he is accidentally exposed to its blood, and finds himself periodically turning into a murderous Neanderthal man.
Teenagers from a small town and their high school science teacher join forces to battle a giant mutant spider, living in a cave nearby and getting hungry.
A man and wife are terrorized by Mad Scientist Dr. Callistratus who was executed but has returned to life with a heart transplant. Along with his crippled assistant Carl, the 'anemic' Mad Scientist, believed to be a vampire, conducts blood deficiency research on the inmates of a prison hospital for the criminally insane to sustain his return to life.
Glenn Manning, "The Amazing Colossal Man," believed dead after falling from the Hoover Dam, reemerges in rural Mexico, brain damaged, disfigured, and very angry.
A group of scientists travel to a remote island to study the effects of nuclear weapons tests, only to get stranded when their airplane mysteriously explodes. The team soon discovers that the tests have given rise to crabs mutated into intelligent, impervious, telepathic giants intent on increasing their numbers by breeding, then travelling to populated areas to feed, and which do not intend to be stopped by their discoverers.
When the first manned flight to Venus returns to Earth, the rocket crash-lands in the Mediterranean near a small Italian fishing village. The locals manage to save one of the astronauts Colonel Calder, the mission commander. A young boy also recovers what turns out to be a specimen of an alien creature. Growing at a fantastic rate, it manages to escape and eventually threatens the city of Rome.
The arrival in a small mountain town of a dissheveled stranger launches a series of murders committed by some sort of animal. As the town doctor and his daughter attempt to help the stranger, the sheriff investigates the murders; and they uncover a sinister experiment involving two rogue scientists, a car accident victim, his wife and children, and a serum that causes a man to turn into a ravaging werewolf.