George Stroud, a crime magazine's crusading editor, has to postpone a vacation with his wife - again - when a glamorous blonde is murdered and he is assigned by his publishing boss to find the killer. As the investigation proceeds to its conclusion, Stroud must try to disrupt his ordinarily brilliant investigative team as they increasingly build evidence that he is the killer.
In 1932, a cop is killed and Frank Wiecek sentenced to life. Eleven years later, a newspaper ad by Frank's mother leads Chicago reporter P.J. O'Neal to look into the case. For some time, O'Neal continues to believe Frank guilty. But when he starts to change his mind, he meets increased resistance from authorities unwilling to be proved wrong.
Centring on the activities of a gang of assorted criminals and, in particular, their leader – a vicious young hoodlum known as "Pinkie" – the film's main thematic concern is the criminal underbelly evident in inter-war Brighton.
Bootleggers on the lam Frankie and Noll split up to evade capture by the police. Frankie is caught and jailed, but Noll manages to escape and open a posh New York City nightclub. 14 years later, Frankie is released from the clink and visits Noll with the intention of collecting his half of the nightclub's profits. But Noll, who has no intention of being so equitable, uses his ex-girlfriend Kay to divert Frankie from his intended goal.
The peaceful life of a gas station owner is disrupted when a man from his past arrives in town and forces him to return to the dark world he had tried to escape.
The Bowery Boys head west to clear Louie of an old murder charge that he had killed his gold-mine partner. Sach has the map to the gold mine painted on his back, and Blackjack McCoy has him kidnapped by Indian Joe. Gabe poses as a dangerous gunman, the Klondike Kid, while Slip is in charge of all the remaining loose ends.
A gang of criminals, which includes a piano player and an imposing former convict known as 'Gruesome', has found out about a scientist's secret formula for a gas that temporarily paralyzes anyone who breathes it. When Gruesome accidentally inhales some of the gas and passes out, the police think he is dead and take him to the morgue, where he later revives and escapes. This puzzling incident attracts the interest of Dick Tracy, and when the criminals later use the gas to rob a bank, Tracy realizes that he must devote his entire attention to stopping them.
Sandra Carpenter is a London-based dancer who is distraught to learn that her friend has disappeared. Soon after the disappearance, she's approached by Harley Temple, a police investigator who believes her friend has been murdered by a serial killer who uses personal ads to find his victims. Temple hatches a plan to catch the killer using Sandra as bait, and Sandra agrees to help.
When his best friend is murdered inside a London dancehall, a cab driver and his girlfriend involve themselves in the investigation and discover a major criminal operation hiding behind the club's friendly facade.
Dick Tracy investigates the theft of a fortune of fur coats, a possible insurance swindle and several murders, all linked to a huge thug who wears a hook in place of his right hand.
Magazine writer Ann Mason infiltrates the United Defenders, a public service organization which is actually a front for racketeers. But a case of amnesia threatens to blow her cover.
Maisie Revere, a showgirl stranded in Los Angeles, decides to join the local police department on the persuasion of Lieutenant Paul Scott who wants to use her as an undercover agent to expose a conman.
War heroes Rip Murdock and Johnny Drake are sent to Washington, D.C, to receive top honors for their service. Johnny, seemingly terrified by the publicity that awaits him, jumps off the train and later turns up dead. Suspecting foul play, Rip begins digging into his pal's past. He encounters cover-ups, threats to his own life and deadly femme fatale Coral Chandler.
Private eye Phillip Marlowe wants to get out of the detective racket and into crime writing. But when he's called to the office of editor Adrienne Fromsett, it's not to talk about his story ideas — she wants him to locate the missing wife of her boss, Mr. Kingsby. The assignment quickly becomes complicated when bodies start turning up.