A gang of criminals, which includes a piano player and an imposing former convict known as 'Gruesome', has found out about a scientist's secret formula for a gas that temporarily paralyzes anyone who breathes it. When Gruesome accidentally inhales some of the gas and passes out, the police think he is dead and take him to the morgue, where he later revives and escapes. This puzzling incident attracts the interest of Dick Tracy, and when the criminals later use the gas to rob a bank, Tracy realizes that he must devote his entire attention to stopping them.
Sandra Carpenter is a London-based dancer who is distraught to learn that her friend has disappeared. Soon after the disappearance, she's approached by Harley Temple, a police investigator who believes her friend has been murdered by a serial killer who uses personal ads to find his victims. Temple hatches a plan to catch the killer using Sandra as bait, and Sandra agrees to help.
When his best friend is murdered inside a London dancehall, a cab driver and his girlfriend involve themselves in the investigation and discover a major criminal operation hiding behind the club's friendly facade.
Maisie Revere, a showgirl stranded in Los Angeles, decides to join the local police department on the persuasion of Lieutenant Paul Scott who wants to use her as an undercover agent to expose a conman.
When a kindly priest is murdered while waiting at a street corner in a quiet Connecticut town, the citizens are horrified and demand action from the police. All of the witnesses identify John Waldron, a nervous out-of-towner, as the killer. District Attorney Henry Harvey is then put on the case and faces political opposition in his attempt to prove Waldron's innocence.
An old man and his sister are concealing a terrible secret from their adopted teen daughter, concerning a hidden abandoned farmhouse, located deep in the woods.
War heroes Rip Murdock and Johnny Drake are sent to Washington, D.C, to receive top honors for their service. Johnny, seemingly terrified by the publicity that awaits him, jumps off the train and later turns up dead. Suspecting foul play, Rip begins digging into his pal's past. He encounters cover-ups, threats to his own life and deadly femme fatale Coral Chandler.
Private eye Phillip Marlowe wants to get out of the detective racket and into crime writing. But when he's called to the office of editor Adrienne Fromsett, it's not to talk about his story ideas — she wants him to locate the missing wife of her boss, Mr. Kingsby. The assignment quickly becomes complicated when bodies start turning up.
A treasury agent on the trail of counterfeit money confides to fellow ocean liner passenger, Charlie Chan, that there have been two attempts on his life.
Two hit men walk into a diner asking for a man called "the Swede". When the killers find the Swede, he's expecting them and doesn't put up a fight. Since the Swede had a life insurance policy, an investigator, on a hunch, decides to look into the murder. As the Swede's past is laid bare, it comes to light that he was in love with a beautiful woman who may have lured him into pulling off a bank robbery overseen by another man.
Private Investigator Philip Marlowe is hired by wealthy General Sternwood regarding a matter involving his youngest daughter Carmen. Before the complex case is over, Marlowe sees murder, blackmail, deception, and what might be love.
A falsely convicted man's wife, Catherine, and an alcoholic composer and pianist, Martin team up in an attempt to clear her husband of the murder of a blonde singer, who is Martin's wife.
"The Unknown" was the final entry in Columbia’s I Love A Mystery series. A woman hires two detectives to keep her alive long enough to claim her inheritance.
After three men are convicted of bank robberies, Charlie becomes suspicious. After some investigation Charlie finds the men are innocent and that the fingerprint evidence used to convict them had been forged. Charlie then proceeds to find the true bank robbers.