During the Civil War, President Abraham Lincoln sends an emissary with a peace treaty to the Sioux Indians. He also sends a gift of $130,000 in gold. This attracts the attention of Brock Marsh, the secret leader of a Confederate spy ring, who wants to keep the treaty from being signed and to also get his hands on the gold. Ruth Lawrence and Mike Daugherty work together against the machinations of Marsh
Following the surrender of Geronimo, Massai, the last Apache warrior is captured and scheduled for transportation to a Florida reservation. On the way he manages to escape and heads for his homeland to win back his girl and settle down to grow crops. His pursuers have other ideas though.
On the outskirts of town, the hard-nosed Vienna owns a saloon frequented by the undesirables of the region, including Dancin' Kid and his gang. Another patron of Vienna's establishment is Johnny Guitar, a former gunslinger and her lover. When a heist is pulled in town that results in a man's death, Emma Small, Vienna's rival, rallies the townsfolk to take revenge on Vienna's saloon – even without proof of her wrongdoing.
Joe Branch, reputed to be the son of Jesse James, comes riding into Coffeyville Kansas, looking for proof one way or the other regarding the question of who his father was.
Brady Sutton returns from three years in prison and tries to go straight. One a member of the Butch Cassidy gang, he is still suspected of being cahoots with them. When Cassidy and his men rob the bank, he is blamed. Escaping from the townspeople, he once again joins up with Cassidy to wait for a chance to help bring him in.
During the Klondike Gold Rush, a misanthropic cattle driver and his talkative elderly partner run afoul of the law in Alaska and are forced to work for a saloon owner to take her supplies into a newly booming but lawless Candian town.
A spirited cast kicks up its heels in a lively musical spoof of cowboy films crammed with spur-jangling tunes by Jay Livingstone and Ray Evans and decked out with colorfully stylized, Oscar.-nominated sets. Rosemary Clooney heads up the high-kicking, red-gartered girls of the Red Dog Saloon. They can-can. but she won't-won't unless Jason (Jack Carson) asks her to get hitched. Guy Mitchell and Gene Barry are gun-totin' polecats who think they've got a feud to settle. And Frank Faylen and Buddy Ebsen are among the folks who hope the gunslingers get itchy fingered - so they can hold a town barbecue during the funeral!
A Confederate officer travels to a wild Mexican border town to buy guns, aiming to keep up the fight against the Yankees - but who can he trust in this lawless place?
Jim Harvey is hired to guard a small wagon train as it makes its way west. The train is attacked by Indians and Harvey, hoping to persuade Aguila, the chief, to call off the attack due to Harvey's having saved his son's life, leaves the train to negotiate. He is captured and the rest of the train is wiped out except for two sisters. Escaping and showing up in town later, Harvey is nearly hanged as a deserter, but gets away. Eventually caught by the sheriff and his posse, they are attacked by Indians. This time the Indians are defeated and Aguila, captured and dying, reveals the identity of the white man who engineered the initial attack on the wagon train, just as the perpetrator rides up behind them.
Sharpshooter Calamity Jane takes it upon herself to recruit a famous actress and bring her back to the local saloon, but jealousy soon gets in the way.