A wagon train heads west from Independence, Mo., along the Oregon Trail, led by proud cowboy Clint Belmet. On board are feisty young widow Nancy Wellington and her toddler, Sonny, as well as the older Abby Masters, who begins a romance with scout Jim Burch. Along the way, the wagon train battles Indians led by Kenneth Murdock, a trapper who doesn't welcome competition for Oregon's lucrative fur trade. Wagon Wheels is a 1934 remake of 1931's Fighting Caravans, using stock footage from the original.
Aspiring singer Susanne takes over one night for her sick friend, a small-time female impersonator, and finds unexpected fame when everyone believes that she is actually a man. While touring London, complications arise as a local womanizer catches on to her game.
A kind-hearted young man is thrown out of his corrupt home town of West Rome, Oklahoma. He falls asleep and dreams that he is back in the days of olden Rome, where he gets mixed up with court intrigue and a murder plot against the Emperor.
When a movie actor is shot and killed during production, the true feelings about the actor begin to surface. As the studio heads worry about negative publicity, one of the writers tags along as the killing is investigated and clues begin to surface.
Steve Drexel voluntarily strands himself on a deserted island on a bet. He intends to re-create civilization and carves a miniature city of 52nd Street and Park Avenue out of the jungle. Drexel is befriended by his dog, a native monkey, and a wild goat that is captured in one of his traps. He attempts to cultivate a native as his Man Friday from Robinson Crusoe, but fails as the native escape.
Musical comedy antics in an art deco bakery (motto: "Glorifying the American Doughnut") where Eddie Cantor, the overworked assistant to a phony psychic, is mistaken for an efficiency expert and placed in charge. Complications ensue when the psychic and his gang attempt to rob the payroll.
A tramp falls in love with a beautiful blind flower girl. His on-and-off friendship with a wealthy man allows him to be the girl's benefactor and suitor.
Two fast-talking insurance salesmen meet Mary, who is running away from her wealthy mother, and they agree to help her run a hotel that she owns. When they find out that the hotel is run down and nearly abandoned, they launch a phony PR campaign that presents the hotel as a resort favored by the rich. Their advertising succeeds too well, and many complications soon arise.
Infamous burglar "The Bat" commits a daring jewelry theft despite heavy police presence. Soon after, a bank theft occurs, which may be the work of the criminal as well. Meanwhile, Cornelia Van Gorder has various people arrive at her old mansion, including her niece, Dale, a bank employee, and police detective Anderson. When guests start turning up dead, Cornelia begins to suspect that The Bat may be lurking around the estate.
Amos and Andy trying to make a go of their "open-air" taxi business while they get caught up in a society hassle, involving driving musicians to a fancy party.
Western sheriff Bob Wells is preparing to marry Sally Morgan; she loves part-Indian Wanenis, whose race is an obstacle. Sally flees the wedding with hypochondriac Henry Williams, who thinks he's just giving her a ride; but she left a note saying they've eloped! Chasing them are jilted Bob, Henry's nurse Mary (who's been trying to seduce him) and others.
A young woman, who wants to be in the Follies, is making ends meet by working at a department store's sheet music department, where she sings the latest hits. She is accompanied on piano by her childhood boyfriend, who is in love with her, despite her single-minded interest in her career. When a vaudeville performer asks her to join him as his new partner, she sees it as an opportunity to make her dream come true. Upon arriving in New York City, our heroine finds out that her new partner is only interested in sleeping with her and makes this a condition of making her a star. Soon, however, she is discovered by a representative of Ziegfeld.
During America’s Civil War, Union spies steal engineer Johnny Gray's beloved locomotive, 'The General'—with Johnnie's lady love aboard an attached boxcar—and he single-handedly must do all in his power to both get The General back and to rescue Annabelle.