Jayaram always wanted to be a doctor, but he became an electrician instead. So his deep desire is to marry a woman doctor, which he does. But things don't turn out as he expected.
The story is about Thilakan and his two adopted sons, one of them blind, Unni (Sreenivasan), and the other one deaf, Balan (Mukesh). The story takes a turn when the sons marry and their in-laws try to steal the family money. Krishnankutty (Jagathy) is the clever but honest caretaker for the deaf and blind siblings who is constantly at odds with their in-laws. The father (Thilakan), carries the burden of sorting things out.
Bhetalam hides stolen gold in a cemetery and before dying, he confesses his sin to a group of travellers. Each individual tries to beat the other in the race to find the fortune.
Mugguru Monagallu is a Action comedy based movie in which, Prithvi, Vikram and Dattatreya (Chiranjeevi in triple role) are the sons of Ranganath and Srividya living in a village. Ranganath goes against Sarath saxena in an incident and is killed by him. Srividya who is pregnant with twins is separated from prithvi thinking that he is killed in escaping from the goons and delivers twins in a temple. The temple saint adopts one son who is childless and srividya is left with vikram who becomes ACP. Dattatreya is a Dance master. The story revolves on how the brothers unite with one another and also with their mother and take revenge on Sarath Saxena.
A young man lies that he got married to impress his boss who hates bachelors and shows a random photo of a girl and claims her as his wife. But when she enters his life, things start to change a lot.
Balaji thinks men can do everything as they are supposed to be the head of the family and earn for them. But he realises his mistake when he loses his job and his wife has to work.
Kittaiah, a simple villager, loves his cousin Saroja, but his maternal uncle disapproves of Kittaiah. Dejected, Kittaiah pleads with Lord Krishna to help him.
Chellappa (Jayaram), an orphan, runs a photo studio in deficit with his friends (Chinni Jayanth and Vadivelu). Mary (Bhanupriya) comes to his village to learn singing to a guru (Kalyan Kumar) and she helps her guru's family in many ways. Kannan (Arjun Sarja), her guru's son, is supposed to be in the city. Chellappa falls in love with Mary and he proposes to marry her. Mary reveals that she was married and she tells him her past. Her real name was Gayatri, she was a rich girl and she was in love with Kannan. Kannan had lot of responsibility and had to help his poor family. Gayatri's guardian (Jaishankar) accepted for their marriage but Vasanth (S. N. Vasanth), his son, also wanted to marry her and sent henchmen to kill him. Kannan died at Gayatri's birthday party where her guardian had arranged for their engagement after Gayatri promised to help his family. Vasanth's father sent his son to jail and he apologized to Gayatri. She went to her friend Mary's village instead of her.
A young man marries a Tamil girl, and fearing his family, he brings her to the house as a servant. Problem starts when his elder brothers falls for her too.
Unni (Jayaram) is in the army, but does not wish to stay there. He feigns a mental illness to get discharged, but has to continue to put on the show in front of his family and villagers when he reaches back home.
Eby, who hails from a wealthy family, falls in love with Ilina, but her family opposes their relationship. At Eby's insistence, her uncle reveals the shocking reason that can change their future.
A newly appointed professor finds that his student has a crush on him and wants to marry him. He ignores her advances and marries an orphan. Not the one to give up, she continues to pursue him.
Two thieves (Mukesh and Sreenivasan) become targets of the two rival crime gangs and the police after they are wrongly accused of attempted murder when robbing a hotel.
A young man in desperate need of money takes up a job as a guardian for a wealthy family and has to disguise himself as an old teacher as per the job requirement.
Vivek, Narayanan and Kannan are admitted in a hospital for treatment. Babu , son of a rich businessman, is also admitted in the same ward as them. They become friends in a short time. They finally come to know that they will live only for few more months, they all have blood cancer. They decide to leave the hospital and to travel. They arrive in a small village where Sivalingam spreads terror among the villagers.
The film starts by displaying an antic of Keshavan (Thilakan) who is an inmate of the Kakkanad Mental Hospital. Two other inmates are Benny (Mukesh) and Krishnankutty (Jagathy Sreekumar), along with the female inmate Philomena. By profession Benny is an artist, Krishnankutty is a mechanic and Keshavan had retired from military service. The late Hakeem Rawther too plays as an inmate in a cameo role. The trio chance to come across a newspaper report that Amitabh Bachchan is visiting Ernakulam City for film shooting, near the place they stay. They are soon joined by Venu (Siddique), as the brother of Balan (N.N.Balakrishnan) who takes him to the mental hospital. Venu is a good singer but has a compulsive obsession to singing. Driven by a desire to see Amitabh Bachchan the four of them manage to escape from the mental hospital that night by ripping off the cell warden Ameen (Mala Aravindan). They reach Ernakulam city in a bus, and hilarity starts