When Decker's gang holds up a stage, henchman Lefty takes a lady's rings. Later lefty accidentally exposes the rings buying ammunition and Cheyenne sees them. When Lefty tries to shoot Cheyenne he is captured. Now Cheyenne wants the rest of the gang and their leader.
"Wicked" Lily Bishop joins a wagon train to California, led by Michael Fabian and Johnny Trumbo, but news of the Gold Rush scatters the train. When Johnny and Michael finally arrive, Lily is rich from her saloon and storekeeper (former slaver) Pharaoh Coffin is bleeding the miners dry. But worse troubles are ahead: California is inching toward statehood, and certain people want to make it their private empire.
Knowing the railroad is coming, Carter is after the rancher's land. Bob and Chito return just in time to save Banker Stockton and his money from Carter's men. When Stockton then lends the ranchers money, Carter has them burned out. Bob knows Carter is responsible and when Carter's henchman Saunders is recognized, Bob goes into action.
Roy is an oil prospector. His efforts to get drilling rights on an old Spanish land grant are countered by gamblers from an off-shore gambling boat determined to control the land (and oil) themselves.
The ranch of Red Ryder (Allan Lane) and his aunt, The Duchess (Martha Wentworth), is being used as the training site for "Gentleman Jim" Corbett (George Turner) for his upcoming fight in Carson City, Nevada for the heavyweight championship against Bob Fitzsimmons (John Dehner). Molly McVey (Peggy Stewart), the daughter of a U.S. Senator, crusading against prize-fighting in Nevada, complicates matters soemwhat when she conceives the bright idea of having Corbett kidnapped, thus causing the cancellation of the fight. The two men (George Chesebro and George Lloyd) she hires to do the kidnapping also add to the complications by kidnapping Ryder instead of Corbett. Meanwhile, a gang of crooks, led by McKean (Roy Barcroft), descend on the town intent on looting the town and also making off with the fight proceeds.
Notorious shootist and womanizer Quirt Evans' horse collapses as he passes a Quaker family's home. Quirt has been wounded, and the kindly family takes him in to nurse him back to health against the advice of others. The handsome Evans quickly attracts the affections of their beautiful daughter, Penelope. He develops an affection for the family and their faith, but his troubled past follows him.
Curt Mason saves Doc Henderson's Medicine Show from being robbed by the Morrell gang but later earns the enmity of Carolyn when he blames the troupe for polluting a local watering hole. Arriving in town, the medicine show, which consists of Doc Henderson, Taffy, the singing group the Hoosier Hot Shots and Carolyn, begin their performance while Curt is unsuccessfully attempting to stop the Morrell gang from robbing the bank. The sheriff mistakes Curt for one of the gang, and to save their friend, Curt's buddies Biscuit and Big Boy stampede their cattle through town. In order to clear his good name, Curt and his friends go in search of the real bank robbers, who as it turns out are working under orders from Doc Henderson.
Driving a herd of cattle to market, Jimmy finds the trail has been fenced off by an old friend of his. While the two sides try to settle the matter peaceably, a man from each outfit get together to try and start a range war between them figuring they will end up with the cattle. When cattle are rustled, Jimmy finds the clue, horses with shoes that make tracks that look like cattle.
Singing cowboy Monte Hale plays "himself" in the Republic western Last Frontier Uprising. Actually, he's not really himself, but a federal agent, dispatched to Texas to buy horses on behalf of the government. Hale runs up against a vicious gang of horse thieves, including such veteran western hard cases as Roy Barcroft and Philip van Zandt. The romantic interest is in the dainty hands of Adrian Booth, who used to go by the name of Lorna Gray. Put together with the standard Republic efficiency, The Last Frontier Uprising benefits from the breathless direction of Lesley Selander.
When the ranchers of Bearcat are plagued by rustlers, Big Jim Grady offers to buy their herds from them at low-ball prices. Steve Haley suggests to the ranchers that they band together and drive their herds to Abilene, Kansas and get full price. Steve's friend Smiley "joins" the rustlers to learn who their leader is. Grady henchman Doc Walker asks Steve to help break up the cattle drive, and he agrees in order to keep tabs on the rustlers. The gang makes several attempts to take the trail herd but Steve, in his guise as the Durango Kid, intervenes and saves the cattle.
Beloved teacher Miss Hinklefink inherits a western ranch, and to spend the summer with Professor Townley, she invites students Freddie, Dodie, Betty, Lee and Roy to join if Townley will co-chaperone. Sketchy real-estate agent Tom Sneed tries to persuade her to send the kids home when desperadoes rob the bank. Sneed's henchman mistakes Freddie for a baby-faced killer framed for a murder actually committed by Sneed, and ranch foreman Big Jim, also working for Sneed, tries to kill Freddie.
Gene Autry is back near the saddle, trying to help out a crippled jockey. Gene is certain that the jockey can ride in the Big Race if the lad can regain his self-confidence. Meanwhile, Gene and comical sidekick Sterling Holloway have another problem on their hands: A rogue stallion has "kidnapped" Gene's prize mare. Piloting a plane, Autry seeks out and locates the stallion.
Johnny Brownell, former Confederate officer turned Federal agent, is sent to Texas during the reconstruction years to obtain evidence against a gang of raiders who have been making life difficult for the local carpet-baggers. He saves the life of Shorty Kendall, an unreconstructed rebel about to be hanged, and this wins him the gratitude of Belle Chambers, a widow whose husband was killed in the Civil War who hates all Yankees with a fever.
A man returning home after having fought in the Civil War discovers that corrupt politicians have taken over the county and are terrorizing and shaking down the citizens. He dons the costume of his ancestor, the famous Zorro, and sets out to bring them to justice.
Caxton has broken out of prison and Eddie has been sent to bring him in. Caxton is known by the polka dot band on his hat and Eddie has Soapy wear one like it. This gets Soapy arrested as soon as he rides into town but it leads Eddie to Varney and he realizes Varney will lead him to Caxton.
Chasing women and staying one step ahead of the law, the Cisco Kid meets Raquel and then Dolores. He sees that Raole is the boy friend of Raquel but engaged to Dolores. Learning that all her money will got to her uncle Don Jose when she marries Raole, Cisco suspects a plot and sets out to unravel it.
Beautiful half-breed Pearl Chavez becomes the ward of her dead father's first love and finds herself torn between her sons, one good and the other bad.