Arriving in Arizona, the band members discover that the hotel is haunted and that it properly belongs to young Jimmy Benson (Curtis), the nephew of the previous owner. The "ghosts," however, turns out to be a trio of confidence men, Zeke Winslow (Guinn "Big Boy" Williams), Noah Jones (Raymond Hatton) and Slim Jensen Victor Potel, who are hoping to buy the place themselves.
Ellen Williams' father has a valuable collection of furs and an outlaw gang is after them. Before he is killed, Williams hides a note revealing their location. The Texas Rangers are on the job and to get more information, they have Panhandle pose as an Indian chief.
Kirby sends his henchmen to break killer Matt Brawley out of jail. But Brawley has already broken out and they return with Fuzzy instead. Realizing they think he's Brawley, Fuzzy plays the part. He and Bill plan to round up the gang but Fuzzy is in trouble when the real Brawley shows up to expose the hoax.
Doris Rogers, half owner of a dude ranch, as Jimmy Wakely, "Lasses" White and Dusty Smith to help run it. U.S. Marshal Tom Logan, posing as a stage driver, is killed during a mock holdup of new arrivals to the ranch. Brenda Amers and Horatio Pennypacker, eastern jewel thieves, bring their loot to Roy Williams, who owns the other half of the ranch as a blind for his gang which resells stolen jewels. Vaughn, the desk clerk, re-cuts the jewels in a secret room in the ice house. Fearing he will be caught, Brenda refuses Williams her stolen diamonds and hides them in a bar of soap.
Heading west for his health, Colonel Lambeth takes his daughter Rill along. Lost on the desert they are saved by Pecos and Chito. The Colonel hires the two and the Lambeths soon find themselves mixed up in Pecos' trouble. Pecos has killed Sawtelle's brother and Sawtelle as head of the vigilantes is after him.
Peggy Barlou is a young rancher who refuses to sell her spread to greedy stage-line proprietor John Rankin. Tex Haines, meanwhile, is accused of killing Bill Dugan, Rankin's bodyguard, but eludes capture long enough to hook up with Dave Wyatt and Panhandle Perkins, a couple of rangers in disguise.
Porky leads a wagon train into "Injun Joe Territory," and finally comes up against the fearsome Superchief. But Sloppy Moe, a survivor of a previous Injun Joe attack, knows something about him he won't tell... until the very end.
An easy-going cowboy is mistaken by the townsfolk for a notorious gunman. The cowboy decides it would be best to leave town, until he meets the gunman's girlfriend.
Fanning has his men rustle horses and then blame it on a wild horse named Wildfire. Happy and Alkali arrive and immediately get into trouble with Fanning and his men. When Alkali is shot, Happy catches the outlaws but the Judge not only releases them, he discharges the Sheriff and tries to arrest Happy for rustling. Happy escapes and he and the Sheriff then set out to prove who the real rustlers are.
Escaping the law, Jim Parker arrives in a town that is controlled by Dalt Higgins and his crony judge. When he stands up to Higgins, he's made sheriff only to be shot in the back. After recovering he returns to get the man that shot him. When the gang attacks, he fights back from the newspaper office. When a stray bullet nicks the printing press plate, Jim sees that it's solid gold and it's not long before the masquerades on both sides of the law are revealed.
A narrator tells the story of how the Western pioneers (all being Goofy lookalikes) are travelling in covered wagons across the frontier. They run into some Indians (who are also Goofy lookalikes) and battle breaks out between them. Suddenly a tornado comes by and sweeps up the covered wagons, dropping them into various states such as "Wash", "Organ", and "Californy."
Bill Harmon receives a letter from his partner, Dave MacRoy informing him of a rich gold strike in their California mine. Arriving there, Bill learns from elderly miner John Benton that Dave is dead and that he sold the mine at a strangely low price the night before his supposed accidental death. Harmon suspects murder.
In this western, the hero fights the bad guys by impersonating the son of a rancher. The outlaws have been making the good landowners pay fake taxes. Not only does the good guy succeed in catching the bad guys, he also catches himself the postmistress.
Flame of the West has always attracted more attention than most of Johnny Mack Brown's Monogram westerns, if for no other reason than the offbeat casting of Douglass Dumbrille. Usually seen in villainous roles, Dumbrille herein offers a sincere, effective performance as a scrupulously honest US marshal named Nightlander. When he takes on a gang of crooked gamblers, Nightlander is shot down in cold blood, compelling frontier doctor John Poole (Johnny Mack Brown) to put his Hippocratic oath on the back burner and strap on the shootin' irons.
Sue Farnum inherits a circus, but her dead father's partner is trying to take it away from her. Roy and Bob Nolan are filming a movie on location at the circus. They and a number of other western movie stars come to Sue's aid, putting on a show and catching the bad guys.
Fuzzy purchases a saloon with a large sack of gold from the mine he owns with his partner Billy. When a crooked lawyer uses underhanded methods to try taking over the saloon, Billy works to bring the lawyer and his no-good gang to justice.