Tom Mix plays Tim, a goodhearted cowpuncher who, while riding down a trail, gets robbed of the money he was carrying for the Belgian Babies' Milk Fund.
A minister and his young daughter Bess, journey west where he hopes to regain his health. They become involved with notorious outlaw 'Eagle' Ryan. The outlaw becomes influenced by the power of religion along with Bess's gentle persuasion, he is reformed from his life of crime and forgiven by all the townspeople.
Although a female, gunfighter "Colonel Billy" is feared by the men of Rattlesnake Gulch, a mining camp in California. The women, however, won't have anything to do with her because of stories about her "loose ways" during the Gold Rush. One day Gerald Morton, an actor, arrives at the camp from San Francisco with his wife Mabel, their baby and preacher Albert Atherton As a prank, the townspeople send Atherton to board with Billy, who is in love with a gold prospector named Faro Bill. Atherton convinces Billy to change her ways; however, Morton strikes gold, and the resulting news reaches San Francisco and attracts a new and different element to Rattlesnake Gulch, resulting in a need for Billy's skills to be used again.
Boss rider "Careless" Carmody is made sheriff of an Arizona frontier town by Chicago swindler Prentice. The naive Carmody actually believes Prentice to be on the up and up and vouches for him in a land deal with Ruth Fellowes. Taken to the cleaners, so to speak, Ruth blames Carmody, who, in love with the girl, follows Prentice back to Chicago.
A young man is lured into a cardgame by a crooked dealer. He is about to lose all the money that was given to him to get medicine for his mother when a local cowboy comes to his rescue.
In this Western, Frank Keenan has a dual role -- kind-hearted gambler John Lynch and evil bandit Big Rivers. The only person who realizes there is a resemblance between the two is dance hall girl Nita (Maude George), who was abused by the outlaw and cared for by Lynch.
Daredevil cowboy Ned Ferguson is hired by John Stafford to stop the cattle rustling plaguing his ranch. On the way to the ranch Ned is bitten by a rattlesnake and is nursed by Mary Radford, who is writing a western novel. Ranch foreman Dave Leviatt tells Ned that Mary's brother Ben is behind the rustling. After Ben and Ned come to an understanding, Dave shoots Ben from under cover but Ben is sure that Ned double-crossed him. Mary will have nothing to do with Ned, even after Ned saves her life during a cattle stampede. Ned finally runs down the rustlers, and Mary sees him as a hero instead of merely putting him in her novel.
Wealthy ranch owner Cheyenne Harry decides he needs a housekeeper, but his cowboys decide he needs a wife and advertise in an eastern newspaper. The ad is answered by Aileen Judson-Brown, as dictated by her fortune-hunting mother. Harry marries Aileen and a baby is born a year later. Deciding to gain more money and social standing, Mrs. Judson-Brown then tries to break up the marriage so that Aileen can marry Ferdie Van Duzen. Mrs. Judson-Brown steals the baby and tells Harry the baby has died and Aileen no longer loves him. Harry goes out West in sorrow, but when Mrs. Judson-Brown's butler wires Harry the truth, Harry locates the baby and discovers Aileen still loves him. The reunited family goes West together, leaving Mrs. Judson-Brown behind.
Young Harry Kenyon returns home to Tondo City after graduating college so he can help his rancher father drive a herd of cattle to the annual market, but a pair of outlaws - Cactus Ben and Tondo Bill - are planning to steal the herd for themselves.