Road Agents begins as a pair of outlaws prepares to rob a stagecoach. Donning masks and brandishing six-guns, the bad guys relieve the passengers of their valuables and also make off with a box full of payroll money. As the sheriff organizes a posse, the bandits are seen dividing their loot. The greedier of the two crooks beats up his partner and absconds with their ill-gotten gains. The other bandit, thirsting for revenge, joins the sheriff's posse to track down his former chum.
A gang of outlaws are planning a bank robbery. After making preparations, they commit the robbery and make their escape amidst a sharp exchange of bullets. They return to their meeting place, and then hurriedly continue onwards, with lawmen close behind them.
A sheriff apprehends a bank robber and recovers the money. On the way back to town, the sheriff loses the recovered money in a crooked card game. The bank robber helps him recover it.
In a saloon in a Mexican border town, a group of cowboys, including a Mexican named Pedro, play poker. One man is discovered cheating, and is shot dead by Pedro, who is wounded as he attempts to escape. Pedro is followed home by the local sheriff, who proves the next victim of Pedro's quick temper and pistol. Pedro's wife, Juanita, is thrown into jail, but he manages to break her out. They head for the border, unaware that a posse is waiting for them.
As a result of a stagecoach hold-up and other crimes, Buck Brady has become known locally as the "King of Bandits". The sheriff posts a $1000 reward for Brady, dead or alive. Soon a full-scale effort is underway to capture the bandit king.
As a young couple are courting, they are rudely interrupted and split up. The man is seized and is turned over to a gang of toughs who want to hang him. Though she is greatly outnumbered, the young woman wastes no time in making a determined effort to rescue him.
A train traveling through the Rockies is held up and boarded by two thugs. They rob the wealthy occupants at gunpoint and then make their getaway by handcar. From there, they hijack a horsecart on a road running parallel to the tracks. Will justice prevail in the end?
A captured Indian marauder is beaten by a gang of cowboys. Seeking vengeance, the Indians attack a stagecoach and abduct its passengers. The cowboys ride in pursuit and successfully rescue the captives.
Shows a band of mischievous cowboys being chased by Indians. A number of shots are fired at the pursuing Indians by the cow punchers, and the Indians' arrows are seen landing in the water pretty close to the fleeing men.