A gang of criminals, which includes a piano player and an imposing former convict known as 'Gruesome', has found out about a scientist's secret formula for a gas that temporarily paralyzes anyone who breathes it. When Gruesome accidentally inhales some of the gas and passes out, the police think he is dead and take him to the morgue, where he later revives and escapes. This puzzling incident attracts the interest of Dick Tracy, and when the criminals later use the gas to rob a bank, Tracy realizes that he must devote his entire attention to stopping them.
Sandra Carpenter is a London-based dancer who is distraught to learn that her friend has disappeared. Soon after the disappearance, she's approached by Harley Temple, a police investigator who believes her friend has been murdered by a serial killer who uses personal ads to find his victims. Temple hatches a plan to catch the killer using Sandra as bait, and Sandra agrees to help.
Jesse James wants to start a new life in a new location, but quickly finds himself wrapped-up in protecting townsfolk from the machinations of evil oilmen.
A neurosurgeon relates to his students in medical school a story about an affair he had with a married woman and how after the affair was over, the woman fell out a window and died. The surgeon, suspecting that she was murdered, set out to find her killer -- but, instead of turning the suspect over to the police, he planned to take his own revenge on the murderer.
Truck driver Mike Lambert is a down-and-out mining engineer searching for a job. When his rig breaks down in a small town, he happens upon a venomous seductress. When her boyfriend robs a bank, they intend to frame Lambert.
Dick Tracy investigates the theft of a fortune of fur coats, a possible insurance swindle and several murders, all linked to a huge thug who wears a hook in place of his right hand.
Art editor Madeleine Damian carries on numerous loveless affairs. After a failed relationship with advertiser Felix Courtland, the increasingly depressed Madeleine attempts suicide. When Jack Garet, her secretary and former lover, tries to blackmail her, Madeleine resigns and seeks a reclusive life. Neighbor David Cousins befriends Madeleine, but soon Courtland and Garet discover her whereabouts and disrupt her new life.
Sach just lost his job as an assistant to a private detective, but he wasn't paid. Slip goes with him down to the detective's office to demand payment, but finds the office empty. A woman enters the office and mistakes Slip for the detective and convinces him to take on a case to find her sister after offering a $50 retainer.
The dream is unusually vivid: Bank employee Vince Grayson finds himself murdering a man in a sinister octagonal-shaped room lined with mirrors while a mysterious woman breaks into a safe. It is so vivid that Vince suspects it may have really happened. To get the dream off his mind, he goes on a picnic with some relatives. When a thunderstorm forces his party into a nearby mansion, Vince discovers that the bizarre room does exist, and it means nothing but trouble.