In the early part of this century, Maddelena a teenage Italian girl, is attacked whilst walking in the woods. The attack leaves her mentally scarred and our story flashes forward to the 1940s where Maddelena is still troubled. She disappears one day and her daughter vows to find her.
The famous Borgia Pearl, a valuable gem with a history of bringing murder and misfortune to its owner since the days of the Borgias, is brought to London, thanks in part to Sherlock Holmes. But before long the jewel is stolen, due to an error on Holmes' part, and shortly thereafter, a series of horrible murders begin, the murderer leaving his victims with their spines snapped and surrounded by a mass of smashed china.
Stephen Neale is released into WWII England after two years in an asylum, but it doesn't seem so sane outside either. On his way back to London to rejoin civilization, he stumbles across a murderous spy ring and doesn't quite know to whom to turn.
When a woman is found dead with her throat torn out, the local villagers blame a supernatural monster. But Sherlock Holmes, who gets drawn into the case from nearby Quebec, suspects a human murderer.
A brother and sister move into an old seaside house that has been abandoned for many years on the Cornwellian coast. They soon discover that it is haunted by the ghost of the mother of their neighbor's granddaughter, with whom the brother has fallen in love.
Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider. Based on "The Sign of Four" and the short stories "The Dying Detective", "The Final Problem", "The Speckled Band" and "The Adventure of the Devil's Foot".
Losing his memories of the last few days, neurologist Dr. Steele is told that his wife has been brutally murdered. Steele, aware of his conniving wife's infidelity, believes he may have been the killer and enlists the aid of his pretty nurse Stella to hypnotize him into recovering his lost memories.
Captain Stone's newly recruited officer, Tom Merriam, idolizes his senior who treats him like a friend. But when a couple of his crew members die mysteriously, Tom starts doubting Stone's authority.
During WWII several murders occur at a convalescent home where Dr. Watson has volunteered his services. He summons Holmes for help and the master detective proceeds to solve the crime from a long list of suspects including the owners of the home, the staff and the patients recovering there.
After young Mary Gibson discovers that her older sister Jacqueline has disappeared, she leaves her boarding school and heads to New York City to track down her sibling. But Mary gets drawn deeper into the mystery.