The villainous Dr. Fu Manchu races against a team of Englishmen to find the tomb of Ghengis Khan, because he wants to use the relics to cause an uprising in the East to wipe out the white race.
When legendary hunter Bob Rainsford is shipwrecked on the perilous reefs surrounding a mysterious island, he finds himself the guest of the reclusive and eccentric Count Zaroff. While he is very gracious at first, Zaroff eventually forces Rainsford and two other shipwreck survivors, brother and sister Eve and Martin Towbridge, to participate in a sadistic game of cat and mouse in which they are the prey and he is the hunter.
In 19th century Paris, a maniac abducts young women and injects them with ape blood in an attempt to prove ape-human kinship but constantly meets failure as the abducted women die.
A circus' beautiful trapeze artist agrees to marry the leader of side-show performers, but his deformed friends discover she is only marrying him for his inheritance.
Dr. Henry Jekyll believes that there are two distinct sides to men - a good and an evil side. He believes that by separating the two, man can become liberated. He succeeds in his experiments with chemicals to accomplish this and transforms into Hyde to commit horrendous crimes. When he discontinues use of the drug, it is already too late.
Henry Frankenstein pieces together body parts in the hope of bringing a human-like creature to life. The mad scientist’s dreams are shattered by his monstrous creation awakening with rage to a world that hates and fears him.
British estate agent Renfield travels to Transylvania to meet the mysterious Count Dracula, who is interested in leasing a castle in London. After Dracula enslaves Renfield and drives him to insanity, the pair sail to London together and Dracula, a secret vampire, begins preying on London socialites.
Infamous burglar "The Bat" commits a daring jewelry theft despite heavy police presence. Soon after, a bank theft occurs, which may be the work of the criminal as well. Meanwhile, Cornelia Van Gorder has various people arrive at her old mansion, including her niece, Dale, a bank employee, and police detective Anderson. When guests start turning up dead, Cornelia begins to suspect that The Bat may be lurking around the estate.
The mysterious Count Orlok summons a happily married real estate agent to his castle, located up in the Transylvanian mountains, to finalise a terrifying deal.