The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.
After his brother's death, Larry Talbot returns home to his father and the family estate. Events soon take a turn for the worse when Larry is bitten by a werewolf.
An obese lawyer finds himself growing "Thinner" when an old Romani man places a hex on him. Now the lawyer must call upon his friends in organized crime to help him persuade the old man to lift the curse. Time is running out for the desperate lawyer as he draws closer to his own death, and grows ever thinner.
Rookie police officer Jessica Loren has been assigned the last shift at a closing police station and must wait for a hazmat crew to collect biomedical evidence. Ordered not to leave the station under any circumstances, Jessica comes to learn that it's more than just an outdated station, it's home to the ultimate embodiment of evil and his devoted bloodthirsty followers. Jessica is left to fend for herself in the Devil's playground.
The small city of Tarker's Mill is startled by a series of sadistic murders. The population fears that this is the work of a maniac. During a search a mysterious, hairy creature is observed. This strange appearance is noticed once a month. People lock themselves up at night, but there's one boy who's still outside, he's preparing the barbecue.
A drive-in favorite, this sci-fi classic follows teenagers Steve and his best girl, Jane, as they try to protect their hometown from a gelatinous alien life form that engulfs everything it touches. The first to discover the substance and live to tell about it, Steve and Jane witness the blob destroying an elderly man, then it growing to a terrifying size. But no one else has seen the goo, and policeman Dave refuses to believe the kids without proof.
A "metal fetishist", driven mad by the maggots wriggling in the wound he's made to embed metal into his flesh, runs out into the night and is accidentally run down by a Japanese businessman and his girlfriend. The pair dispose of the corpse in hopes of quietly moving on with their lives. However, the businessman soon finds that he is now plagued by a vicious curse that transforms his flesh into iron.
The Djinn having been released from his ancient prison seeks to capture the soul of the woman who discovered him, thereby opening a portal and freeing his fellow Djinn to take over the earth.
A vengeful spirit has taken the form of the Tooth Fairy to exact vengeance on the town that lynched her 150 years earlier. Her only opposition is the only child, now grown up, who has survived her before.
On the Caribbean island of Matul, white doctor David Menard is trying to stem the tide of cannibal zombies that are returning from the dead. Arriving on the island are Anne and reporter Peter West who are looking for Anne's missing father. The pair soon find themselves under attack from the zombies.
A Serbian émigré in Manhattan believes that, because of an ancient curse, any physical intimacy with the man she loves will turn her into a feline predator.
A decade after a tragic mistake, family man Chas Chandler and occult detective John Constantine set out to cure his daughter Trish from a mysterious supernatural coma.
An ambitious anthology film featuring segments directed by over two dozen of the world's leading talents in contemporary genre film. Inspired by children's educational ABC books, the film comprises 26 individual chapters, each helmed by a different director assigned a letter of the alphabet. The directors were then given free reign in choosing a word to create a story involving death.
Two teenage boys unwittingly summon an ancient evil entity known as The Blind One by delving into black magic while trying to escape their mundane lives.