The story takes place in the Bakumatsu era in Kyoto. A solider who has lost his memories is aided by the famous Shinsengumi member Sōji Okita. Sōji Okita names this man "Junsuke Tachikawa." Junsuke's life begins anew amidst the Mibu soldiers.
Teenage game player Lu Lu inadvertently enters a game, becoming the villain Yin Er San. She then has to fully upgrade to complete the task of overcoming the demons while she explores the male protagonist's romantic feelings.
After dying in a bus accident, workaholic Arihito is reincarnated in Labyrinth Country, where reincarnators fight monsters. Rejecting his demanding manager Kyouka, he begins his adventure as a "Rearguard."
Following the conclusion of the greatest father-son fight on earth, Baki and other legendary fighters are overcome with unbearable boredom. Meanwhile, 364 meters beneath Tokyo Skytree, a secret plan is set into motion that seeks to revive the master swordsman Miyamoto Musashi... Unleashed in the present day, this menacing new threat wields his swordsmanship with unparalleled power and speed to attack Baki and the others.
Garo focuses on Kouga Saezima, the current possessor of the title, Golden Knight Garo, who protects humanity against dark demonic infestations called Horrors. One day he meets a young girl named Kaoru whom he saves from a horror, but gets stained with horror's blood. The makai knights have the rule that those that have been stained by the blood of a horror shall be executed before experiencing a painful death after approximately 100 days.