Timid milkman, Burleigh Sullivan, somehow knocks out a boxing champ in a brawl. The fighter's manager decides to build up the milkman's reputation in a series of fixed fights and then have the champ beat him to regain his title.
A super-efficient secretary at a department store falls for and marries her boss, but finds out that taking care of him at home (and especially his spoiled-brat daughter) is a lot different than taking care of him at work.
A disparate group of people meet as passengers on a superspeed train crossing the U.S. Aboard are a seductive blackmailer and the stage director he intends to frame, a woman chasing her husband who is running away with the blackmail victim, and the stage director's feisty leading lady.
Grant hides stolen money in the luggage of Bonnie Shea who is moving west. Later when he and his men arrive to retrieve the money, they also kidnap Bonnie. This sends Reasonin' Bates and his cowhands on their horses after the gangsters in their cars.
Hard-boiled newspaper reporter Larry Doyle (Robert Armstrong) goes a bit too far in celebrating a work bonus and wakes up on a train bound for St. Louis with only a buck on his person. To remedy the problem, Doyle pawns the revolver he's carrying. When the gun is subsequently used in a murder, Doyle's problems only multiply. In the meantime, he's also fallen in love with a comely stranger (Maxine Doyle) he convinced to impersonate his wife.
Down-on-his-luck film director Jimmie Dale takes a job at a fly-by-night acting school. He is drawn into the plans of the school's owner to bilk a wealthy young man out of the funds he has supplied to shoot a movie starring pretty student Alice Perkins. But Jimmie hopes to bilk the bilkers by actually completing the movie as ostensibly planned.
Gangster Chandler and his accomplice Tracy arrive at a dude ranch. Cowboy Kentucky arrives at the same time. When Tracy double-crosses his boss and has the stage robbed, Kentucky finds the outlaws and brings them in. Tracy frames him for the murder of the driver but his pal Cactus gets him out of jail. He returns just as Chandler shoots Tracy and Kentucky finds himself arrested for another murder.
Two military pilots are close friends, and share in a lot of hazardous missions while engaging in a series of good-natured romantic rivalries. But when one of the pilots loses a girl he really cared for, he cannot forgive his friend. Soon afterwards, they must work together on their most dangerous mission yet.
A wagon train heads west from Independence, Mo., along the Oregon Trail, led by proud cowboy Clint Belmet. On board are feisty young widow Nancy Wellington and her toddler, Sonny, as well as the older Abby Masters, who begins a romance with scout Jim Burch. Along the way, the wagon train battles Indians led by Kenneth Murdock, a trapper who doesn't welcome competition for Oregon's lucrative fur trade. Wagon Wheels is a 1934 remake of 1931's Fighting Caravans, using stock footage from the original.
Judge Priest, a proud Confederate veteran, restores the justice in a small town in the Post-Bellum Kentucky using his common sense and his great sense of humanity.
Señor Martinez, a famous theater owner, visits a local café in Mexico because of its reputation for good food and to audition the famous dancer who performs there. Martinez tells the café owner that if the dancer is as good as he has heard, he will offer the dancer a contract to perform in his theater. The café's female singer hears about this and is determined that he won't leave the café without her.
When attacked by two dogs, Joe Gilmore leaves them on the desert to die. Later one of the dogs saves John Blake from drowning. Men arrive claiming the dog is killing their chickens. They want to kill the dog but John convinces them the dog's fate should be determined by a trial.
When the chemical company owned by eccentric Professor Higginbottom files for bankruptcy, the formerly-affluent family loses its income. Levelheaded oldest daughter Lambie struggles to make ends meet but has trouble persuading her carefree, profligate siblings to cut down on their spending. Youngest brother Dick enters a motorcycle race to win $500, but crashes his bike on the speedway and is paralyzed. Shocked into reality by the tragedy, Lambie's younger sister Babs persuades ex-prizefighter Gunboat Bimms to enter the ring one last time in hopes of winning a purse that will pay for Dick's surgery.
Tom Collier has had a great relationship with Daisy, but when he decides to marry, it is not Daisy whom he asks, it is Cecelia. After the marriage, Tom is bored with the social scene and the obligations of his life. He publishes books that will sell, not books that he wants to write. Even worse, he has his old friend working as a butler and Cecelia wants him fired. When Tom tries to get back together with Daisy to renew the feelings that he once felt, Daisy turns the tables on him and leaves to protect both of them.
When a movie actor is shot and killed during production, the true feelings about the actor begin to surface. As the studio heads worry about negative publicity, one of the writers tags along as the killing is investigated and clues begin to surface.