A half Mexican, half Irish gunman called The Irish Gringo and his pals come across a little girl wandering in the desert. It turns out her grandfather was murdered by a gang looking for the Lost Dutchman mine, a map of which is drawn on the shirt she is wearing, and now the outlaws are after her.
Traveling with Doc Parker's medicine show, Gene finds his old friend Harry Brooks wounded and the Sheriff after him for murdering his father. Gene also sees that Craven and his gang are looking for Brooks. Finding clues that Craven was behind the murder, Gene has a plan utilizing the medicine show wagon that will trap the gang.
A wagon train heads west from Independence, Mo., along the Oregon Trail, led by proud cowboy Clint Belmet. On board are feisty young widow Nancy Wellington and her toddler, Sonny, as well as the older Abby Masters, who begins a romance with scout Jim Burch. Along the way, the wagon train battles Indians led by Kenneth Murdock, a trapper who doesn't welcome competition for Oregon's lucrative fur trade. Wagon Wheels is a 1934 remake of 1931's Fighting Caravans, using stock footage from the original.
Señor Martinez, a famous theater owner, visits a local café in Mexico because of its reputation for good food and to audition the famous dancer who performs there. Martinez tells the café owner that if the dancer is as good as he has heard, he will offer the dancer a contract to perform in his theater. The café's female singer hears about this and is determined that he won't leave the café without her.
Unscrupulously ambitious, Brutus Jones escapes from jail after killing a guard and, through bluff and bravado, finds himself the emperor of a Caribbean island.
Vaudevillian Joe Pitt sweeps young Sally Patter off of her feet and steals the lovestruck girl away from her small-town family to join his act. She winds up heartbroken, pregnant and broke when Joe runs off with the magician's sexy assistant. Sally bravely persists and her immense dancing and singing talent gain the notice of prominent producer, Wade Valentine. Under Valentine's tutelage, she rockets to Broadway stardom while Joe Pitt is reduced to waiting on tables. Alone, Sally proudly gives birth to a baby son. Wade proposes marriage to his beloved protege and it appears that Joe Pitt may never learn about the son he has fathered.
A singer on a gambling ship is married to a wealthy playboy. When he is found murdered, all evidence points to her as the culprit, and she is put on trial for the crime.
A circus performer falls in love with the son of a plantation owner in antebellum New Orleans. When the young man's stepmother objects to the wedding, the couple break apart and go their separate ways for a time. Also in the mix are two circus comics who feud over the heart of another Southern belle.