A ranger in Buffalo Gap has been killed and the trail leads to a gang headed by Bill Judd. When there is yet another killing, the sheriff seems remarkably hesitant to arrest the culprit and may be taking his orders from a mystery boss. Teaming up with Al's pretty sister and her Uncle Bob, Cheyenne and Fuzzy go in search of the mystery villain.
Two con-men from the East come out West to join up with Avery. They plan to steal the Lopez diamond from Don Lopez. With the drought, Lopez has sold all of his other jewels for gold so that he can take his people to a better place to live and work. Dean and Soapy try to protect Lopez, but Avery and his gang steal the gold and look forward to stealing the diamond necklace. When Maria offers to become partners with Barrit, it looks bad for Lopez.
Singing cowboy Eddie Dean and his sidekick Soapy (Roscoe Ates) enter into the thick of things when they thwart a stagecoach holdup. Our heroes take it upon themselves to champion the cause of stage-line owner Margie Rodgers (Helen Mowery), who's being victimized by an unknown villain. Dean suspects that there's more to the case than mere robbery, and he's right: someone wants to gain control of Margie's business, and that someone is?
Notorious shootist and womanizer Quirt Evans' horse collapses as he passes a Quaker family's home. Quirt has been wounded, and the kindly family takes him in to nurse him back to health against the advice of others. The handsome Evans quickly attracts the affections of their beautiful daughter, Penelope. He develops an affection for the family and their faith, but his troubled past follows him.
Caxton has broken out of prison and Eddie has been sent to bring him in. Caxton is known by the polka dot band on his hat and Eddie has Soapy wear one like it. This gets Soapy arrested as soon as he rides into town but it leads Eddie to Varney and he realizes Varney will lead him to Caxton.
Newcomer Monte Hale is tying to just get a job in western films when he meet young Danny McCoy and his sister Gloria. Danny is trying to get his horse, "Pardner" into films. Monte sings a song and "Pardner" does some tricks and a casting director notices. Monte gets a singing-cowboy role and the horse gets a bit, but there is an accidental explosion, engineered by western star Rod Mason, who is jealous of Monte, and the horse is badly scared and blows his lines.
Eddie and his sidekicks have been called in to help get a new telegraph line through. Dawson and his men along with his stooge Judge are out to stop them. When Eddie and the boys catch three of Dawson's men destroying telegraph equipment, the Judge releases them and this leads to the showdown between the two sides.
Eddie Dean is a Cattlemen's Association agent investigating a serious rash of rustlings along with sidekicks Soapy (Roscoe Ates) and Waco (Lee Bennett. The latter bears a striking resemblance to Lawrence ranch foreman Bert Ford (also Bennett), who has been the target of several assassination attempts. Rancher Lawrence (Lee Roberts) and Eddie decide that Waco shall impersonate Ford, who is hiding out in a hotel room.
Eddie Dean (Eddie Dean) and his partner Soapy Jones (Roscoe Ates), under government orders, proceed to the ranch of J.C. Morgan (Shirley Patterson to buy cavalry remounts for the Army. At the ranch, they find out that J.C. is a girl. The nearby town of Dow City is under the control of a lawless trio headed by Trigger (Lee Roberts, Clem Kensington (Foxy Callahan) and Joe Morino (Dennis Moore). A member of the gang is Tucson Brown (Lee Bennett), one of J.C.'s trusted hands. When Eddie decides to buy the horses, Tucson steals the herd to prevent the sale. Soldiers, sent to investigate, are brutally murdered. The aroused townspeople elect Tennessee (William Fawcett, J.C.'s foreman, as sheriff. When the outlaws murder Tennessee, Eddie and Soapy, along with the reformed Tucson, swing into action.
Eddie Dean's assignment is to thwart the efforts of a crooked gambler, Brad Barton, to take over the property of his half-brother Bill Ryan. In order to secure the ranch, which is believed to hold large silver deposits, the scheming relative contracts to have Ryan killed. He then presents a forged will to the court naming himself as the sole heir. Shocked by the tide of events, Ryan's two rightful heirs, his grown daughter Robin and young son "Freckles" are determined to remain on their father's property. Eddie and his sidekick, Soapy Jones, arrive on the scene in time to enter the fight on the side of Robin and "Freckles."
Medicine show proprietor Doc Lattimer has in his possession a map showing the location of a cache of stolen gold. His son Don favors keeping the gold rather than returning it to the express company to which it rightfully belongs, and steals the map, only to find himself menaced by outlaw leader Cal and his gang.
Duke Dillon has his gang robbing stagecoaches carrying gold which is then melted down by his father. But Eddie and his sidekick Soapy are on the job and they are aided by undercover man Nevada.
Dawson is running rustled cattle across the abandoned Trenton ranch and has given it the reputation of a ghost ranch to keep people away. When Henty Tenton arrives from England to take over the ranch, Dawson tries to get rid of him. But Billy and Fuzzy are on hand to help Henry and it's not long before they have to go into action.
Roy visits his home town while on a personal appearance tour. While there he enters a pony express race. To keep him from winning, bad guys try to sabatoge Roy's entry. They fail, or course. Songs include the title song and "Smile for me, Senorita."
While Fuzzy is waiting for his mail order bride, McCallister frames him for murder. McCallister then advises Matilda to marry Fuzzy so she will get the money when he is hung. But Billy breaks up the wedding and goes after the real killer.