When three women living on the edge of the American frontier are driven mad by harsh pioneer life, the task of saving them falls to the pious, independent-minded Mary Bee Cuddy. Transporting the women by covered wagon to Iowa, she soon realizes just how daunting the journey will be, and employs a low-life drifter, George Briggs, to join her. The unlikely pair and the three women head east, where a waiting minister and his wife have offered to take the women in. But the group first must traverse the harsh Nebraska Territories marked by stark beauty, psychological peril and constant threat.
New Mexico Territory, 1880. Rio Cutler and his older sister Sara must abandon their home after an unfortunate event happens. In their desperate flee to Santa Fe, they cross paths with the infamous outlaw Billy the Kid and his gang, who are ruthlessly pursued by a posse led by Sheriff Pat Garret.
An ex-con seeks revenge on the man who put him in prison by planning a robbery of the latter's stagecoach, which is transporting gold. He enlists the help of a partner, who could be working for his nemesis.
In a remote corner of the wild country, a bloody war rages. Travis is a bounty hunter with one last hope of redemption. Gutjuk is a young Indigenous man trying to save the last of his family. Together they embark on a manhunt, which unravels a secret that ultimately pits them against each other.
At a Mexican ranch, fugitive O'Malley and pursuing Sheriff Stribling agree to help rancher Breckenridge drive his herd into Texas where Stribling could legally arrest O'Malley, but Breckenridge's wife complicates things.
Clay Lomax, a bank robber, gets out of jail after an 7 year sentence. He is looking after Sam Foley, the man who betrayed him. Knowing that, Foley hires three men to pay attention of Clay's steps. The things get complicated when Lomax, waiting to receive some money from his ex-lover, gets only the notice of her death and an 7 year old girl, sometimes very annoying, presumed to be his daughter.
Jim Slater's father (whom he never knew) died in the Apache ambush at Gila Valley, and Jim is searching for the one survivor, who supposedly went for help but disappeared with a lot of gold. In the process, he gets several people gunning for him, and he keeps meeting liberated woman Karyl Orton, who may be on a similar mission. Renewed Apache hostilities and an impending range war provide complications.
Imprisoned for a murder he did not commit, John Brant escapes and ends up out west where, after giving the local lawmen the slip, he joins up with an outlaw gang. Brant finds out that 'Jones', one of the outlaws he has become friends with, committed the murder that Brant was sent up for, but has no knowledge that anyone was ever put in jail for his crime. Willing to forgive and forget, Brant doesn't realize that 'Jones' has not only fallen for the same pretty shopgirl Brant has, but begins to suspect that Brant is not truly an outlaw.
When Sheriff Jake sees a man at the safe and then finds the payroll gone, he trails him. Just as he is about to arrest him, the man saves his life. Still suspicious, he joins up with the man and later they learn that Melgrove, the towns leading citizen, is trying to take over the area's ranches by having his gang stop all incoming supply wagons. With the ranchers about to sell to Melgrove, the two newcomers say they will bring in provisions.
At the end of the Civil War, Frank and Jesse James and other former guerillas who rode with Quantrill and Bill Anderson take the oath of allegiance to the Union. Feeling oppressed by Chicago railroad investors, the James and Younger brothers, Bob and Charlie Ford, Clell Miller and Arch Clements take to robbing banks, trains and coaches, with Pinkerton sworn to bringing them to justice.
Chris Morrell, the guardian of half-Indian girl Nina, is helping her find her missing white father. so she can cash in on her late mother's oil lease. Outlaw Sam Black is after the girl and her father as well. Besides dealing with the Black gang, Morrell has to find another robber, Jim Moore, who switches clothes with him after he finds Chris unconscious from a fight with Sam Black. Along the way, he meets a lady who's the sister of Jim Moore, another bad hombre who's in cahoots with Jim Moore, and an old friend who takes in Nina and helps Chris locate Nina's father and fight off the various desperadoes
The only business in the Wild West town of Jericho that corrupt sheriff Alex Flood doesn't control behind the scenes is the stagecoach owned by tough-willed widow Molly Lang and her right-hand man, Hickman. Former marshal Dolan, recently hired by Lang and Hickman as a driver, wants to stay out of the mess, but when he sees Flood's henchman Yarbrough assault Lang, he steps up to fight the corruption.
Jerry Mason, a young Texan, and Jake Benson, an old rancher, become partners and strike it rich with a gold mine. They then find their lives complicated by bad guys and a woman.
Sheriff John Higgins quits and goes into prospecting after he thinks he has killed his best friend in shooting it out with robbers. He encounters his dead buddy's sister and helps her run her ranch. Then she finds out about his past.
Bandits lead by Matt the Mute enter a bar and kill multiple people. Randy Bowers comes to town and is framed by Matt the Mute, who is working with the sheriff (who doesn't know Matt is really a criminal). Randy escapes with the help of the niece of the dead owner of the bar. Bowers ends up running from the sheriff, and ends up in the cave in which the bandits have their hide-out…
When John Mason's father is killed, John is wounded. Attracted to his nurse Alice, a conflict arises between him and his friend Ben who plans to marry Alice. John later finds the killer of his father but goes to face him not knowing Ben has removed the bullets from his gun.