Luke Barrett, having lost his memory due to an accident, does not realize that Dingus had killed his wife and brother to take possession of the Barretts' land and money. At first Luke trusts him, but while looking for his forgotten identity he discovers the truth.
When the lead robber in their gang steals the money from his two companions, a cat and mouse/back and forth game plays out as the men try to get the money for themselves. But another player, the heir of the sneaky gang leader, is also on the hunt...
The bandit Pratt, looking for Tim, who is responsible for the death of his two sons, attacks a caravan killing all the passengers. Harry, the vagabond, after having robbed the dead, casually meets Tim and they become friends. Running away together from Pratt, they reach Harry's farm, but their hiding place is soon discovered.
Ken Dakota's search for the murderer of his brother, killed by bandit Gary Stevens, at the behest of land owner Chris Malone. Dakota attempts to bring the men responsible for his brothers death to justice.
William Shatner plays two roles: cowboy Johnny Moon and his ruthless Indian twin brother, Notah. Notah likes peyote and gets the crazy idea that he's the Comanche messiah sent to lead the Comanche nation against the white man but more specifically the dusty desert town of Rio Hondo. Moon, estranged from his brother, decides to stop Notah either by words or by bullets.
Marshall Jed Cooper survives a hanging, vowing revenge on the lynch mob that left him dangling. To carry out his oath for vengeance, he returns to his former job as a lawman. Before long, he's caught up with the nine men on his hit list and starts dispensing his own brand of Wild West justice.
Dominated by men in her youth, Belle Starr now out-shoots and out-gambles them as she makes her way around the West. One man who's her equal is Larry Blackie with whom she has an on-again, off-again relationship. Together they become involved in a robbery which goes awry....
After years of hard work, old Sam Cooper has finally found a gold mine. Since he cannot take everything he has found with him, he blows up the entrance. To help him exploit his discovery, he calls on his godson Manolo Sanchez. But Manolo is accompanied by "the blond," a strange man who seems to dominate him. Sam has no choice but to accept his company. He persuades his old friend Mason to travel with them as well. Greed and paranoia will eventually completely destroy the small band.
Django returns home to find out that his father has been killed, by local bandits, in a business deal gone wrong . He swears revenge and a mixture of lone gun men, gang members and bandits get involved with the search for a pouch of money, missing from the ill-fated deal.
Marshal Wyatt Earp kills a couple of men of the Clanton-gang in a fight. In revenge Clanton's thugs kill the marshal's brother. Thus, Wyatt Earp starts to chase the killers together with his friend Doc Holliday.
Bill Meceita, a boy whose family was murdered in front of him by a gang, sets out 15 years later to exact revenge. On his journey, he finds himself continually sparring and occasionally cooperating with Ryan, a gunfighter on his own quest for vengeance, who knows more than he says about Bill's tragedy.