While the Civil War rages on between the Union and the Confederacy, three men – a quiet loner, a ruthless hitman, and a Mexican bandit – comb the American Southwest in search of a strongbox containing $200,000 in stolen gold.
The Man With No Name enters the Mexican village of San Miguel in the midst of a power struggle among the three Rojo brothers and sheriff John Baxter. When a regiment of Mexican soldiers bearing gold intended to pay for new weapons is waylaid by the Rojo brothers, the stranger inserts himself into the middle of the long-simmering battle, selling false information to both sides for his own benefit.
During a shootout in a saloon, Sheriff Hunt injures a suspicious stranger. The doctor's assistant, wife of the local foreman, tends to him in prison. That night, the town is attacked and they both disappear—only the arrow of a cannibal tribe is found. Hunt and a few of his men go in search of the prisoner and the foreman's wife.
Marshall Jed Cooper survives a hanging, vowing revenge on the lynch mob that left him dangling. To carry out his oath for vengeance, he returns to his former job as a lawman. Before long, he's caught up with the nine men on his hit list and starts dispensing his own brand of Wild West justice.
A family of homesteaders taken captive by a gang of outlaws. Their survival comes to rest in the hands of Irene: a loud-mouthed 12-year-old girl who's got an uncanny knack for shooting guns.
Opportunistic con man Dan Kehoe ingratiates himself with the cantankerous mother of four outlaws and their beautiful widows in order to find their hidden gold.
A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
A widowed farmer and his son warily take in a mysterious, injured man with a satchel of cash. When a posse of men claiming to be the law come for the money, the farmer must decide who to trust. Defending a siege of his homestead, the farmer reveals a talent for gun-slinging that surprises everyone calling his true identity into question.
A down-and-dirty town is forced to shape up when a new marshal (Clint Walker) comes to town. However, when a scheme is launched to destroy the lawman's authority, he must discover the perpetrators and preserve his reputation.
The arrival of the telegraph put Pony Express riders like John Blair and his pal Smoky out of work. A race will decide whether they or stageline owner Drake get the government mail contract.
When a black Civil War veteran becomes co-owner of the southern McMasters ranch, the incensed local Confederate veterans come gunning for him and his Indian wife.
Following the Civil War, headstrong rancher Thomas Dunson decides to lead a perilous cattle drive from Texas to Missouri. During the exhausting journey, his persistence becomes tyrannical in the eyes of Matthew Garth, his adopted son and protégé.
Ageing, wealthy, rancher and self-made man, George Washington McLintock is forced to deal with numerous personal and professional problems. Seemingly everyone wants a piece of his enormous farmstead, including high-ranking government men and nearby Native Americans. As McLintock tries to juggle his various adversaries, his wife—who left him two years previously—suddenly returns. But she isn't interested in George; she wants custody of their daughter.
When Sheriff Jake sees a man at the safe and then finds the payroll gone, he trails him. Just as he is about to arrest him, the man saves his life. Still suspicious, he joins up with the man and later they learn that Melgrove, the towns leading citizen, is trying to take over the area's ranches by having his gang stop all incoming supply wagons. With the ranchers about to sell to Melgrove, the two newcomers say they will bring in provisions.
In 1916, during the Mexican Revolution, General Pancho Villa manages to escape from the clutches of General Goyo, his greatest enemy, only to face an even greater problem when he meets McDermott, a mysterious adventurer who promises to get him weapons and ammunition for his troops.
The Marshal sends John Weston to a rodeo to see if he can find out who is killing the rodeo riders who are about to win the prize money. Barton has organized the rodeo and plans to leave with all the prize money put up by the townspeople. When it appears that Weston will beat Barton's rider, he has his men prepare the same fate for him that befell the other riders.