Overland mail riders Jack Mason and his pal, Porchy, learn that an Indian uprising is imminent because one of the tribe has been murdered by a gang of outlaws. The primary town of the mail route is also being used as a hideout and base of operations for a gang of counterfeiters led by Joe Polini. Jack and an undercover federal agent, Duke Evans, round up the counterfeiters and turn Polini over to the Indian Chief as the killer of the brave.
Ann Fenwick is a witness to a bank robbery in the U.S. and the bandits, led by Trigger and Leon capture her and when she disappears, a warrant is issued for her arrest as a material witness. The bank robbers flee across the border into Canada where they steal a trailer in which they lock Ann and the loot. The hitch breaks and the trailer plunges into a lake. Sergeant Renfrew and Constable Kelly, of the Canadian Mounties, rescue Ann and she tells them she is a hitch-hiking tourist and gives a false name. Renfrew sends Kelly for aid, Ann escapes and Kelly returns with the news that she is wanted. The leader of the gang, Cardigan, sends the gang back for Ann and the loot, which Ann has hidden in a trappers cabin, just before Trigger recaptures her. Renfrew goes to her rescue, but is also captured. But reliable Constable Kelly is somewhere in the woods.
Roy is a Confederate officer stationed in Missouri during the Civil War. He must put an end to outlaw gangs working under the pretense of service to the Confederacy.
El Puma, a Mexican desert guide, escorts an archaeological expedition headed by Professor Lucius Lloyd through the Indian badlands of Mexico. Marian, the professor's niece accompanies the party as only she can translate the Aztec writings in the diary of her father, murdered on a similar expedition six years previous. The professor is murdered by a knife, and the weapon is recognized as the property of El Puma. Magpie, a Federal Investigator, knows that El Puma is really "Lightnin' Bill' Carson, a former federal agent who has been missing since Marian's father was slain. The reluctant Magpie believes that his old pal is guilty. Carson sets out to prove otherwise.
Cartwright's racket is to sell a ranch and then have Mason and his men drive the ranchers away so he can resell it. If they want their money back he gives it to them and then has them killed. Jack arrives and learns that Mason and his men are the culprits but that they have a boss. He suspects Cartwright and sets trap to expose him.
The Rancho Grande, a Texas border ranch, cut off from the law by a gang of outlaws led by ranch foreman Bart Lane, who is holding the elderly owner of the ranch, Sarah Burton, a prisoner. Tex Lowery, an undercover Texas Ranger, rescues Martha Williams, a nurse sent for by the ailing Sarah, from a stagecoach holdup by Lane's henchmen. He later convinces Laner that he is a wanted outlaw named Ed Carter, and gains entry to Rancho Grande. But the real Ed Carter shows up.
Before he was killed, Martin hid a half million dollars worth of bonds on his ranch. Brainard, who killed him, Inspector Carson posing as Sam Brown, and Martin's niece Margaret all want the ranch, and it's being sold at auction.
When his ranch falls on hard times, Cowboy Roy Roger has trouble making his mortgage payment and he takes his song and dance to Wall Street to try to raise cash fast.
In an effort to get Jim Martin to sell his ranch, the Halsey brothers have kidnapped his son Tom. When Bob Burke goes after him alone, he gets help from the gang known as the Riders of the Sage.
When his well-meaning sidekick (Smiley Burnette) buys a cow farm instead of a cattle ranch, singing cowpoke Gene Autry prepares to embrace the dairy business. But with a corrupt association bent on driving up milk prices, it's up to newly elected Sheriff Gene to clean up the mess. Country music icon Patsy Montana sings "I Want to Be a Cowboy's Sweetheart," while radio crooners the Texas Rangers perform alongside Autry.
Hoppy goes to town to help Marshal Windy with some rustlers and winds up helping the widow Joyce when confidence men try to take her herd. King's Men songs include: "Hi Thar Stranger" and "Lazy Rolls the Rio Grande."
John Abbott returns to the desert land he owns, and after being wounded by hired gunman Chick Chance, he is befriended by rancher Andrew Naab and his son, Marvin. Naab's daughter, Marian, falls in love with John but is about to marry Snap Thornton to keep a promise made by her father. She runs away on her wedding day but is captured and held hostage by outlaw Henry Holderness. John, the Naabs and fellow ranchers rush to her rescue.
Americans come west to California in the hope of peaceful settlement. Roy and Gabby sing a duet: "We're Not Coming Out Tonight." Other songs include "Sundown on the Rangeland" and "Ride on Vaquero."
Tex arrives on the Parker ranch on Christman eve and is given the job of being Santa Claus. Also dressed as Santa Claus, Blackie robs Parker and kills a man. When Tex is arrested for the murder, he escapes and joins up with outlaw Becker and his gang. He finds Blackie's Santa Claus suit but is soon made a prisoner.
Cavanaugh and McCauley are after the ranchers land. When the Government announces the land will be put up for auction, the ranchers pool their money only to have it stolen by Cavanaugh's men. They then plan to sell their cattle but Cavanaugh announces a fake gold strike and the cowhands all leave. But Gene's hobo friend the Judge says he will get the cattle to market and he sends out a signal to his hobo friends.
Two young brothers are separated when their wagon train is attacked and their parents killed. One brother Cherokee is raised by Indians and the other, the Kansas Kid, by the outlaw gang leader Buff. Twenty years later they unknowingly meet again when the Kid goes after wagons being guided by Cherokee.