While the Civil War rages on between the Union and the Confederacy, three men – a quiet loner, a ruthless hitman, and a Mexican bandit – comb the American Southwest in search of a strongbox containing $200,000 in stolen gold.
Looking to mine for gold, greedy industrialist Bartholomew Bogue seizes control of the Old West town of Rose Creek. With their lives in jeopardy, Emma Cullen and other desperate residents turn to bounty hunter Sam Chisolm for help. Chisolm recruits an eclectic group of gunslingers to take on Bogue and his ruthless henchmen. With a deadly showdown on the horizon, the seven mercenaries soon find themselves fighting for more than just money once the bullets start to fly.
As the railroad builders advance unstoppably through the Arizona desert on their way to the sea, Jill arrives in the small town of Flagstone with the intention of starting a new life.
The Man With No Name enters the Mexican village of San Miguel in the midst of a power struggle among the three Rojo brothers and sheriff John Baxter. When a regiment of Mexican soldiers bearing gold intended to pay for new weapons is waylaid by the Rojo brothers, the stranger inserts himself into the middle of the long-simmering battle, selling false information to both sides for his own benefit.
Legendary marshal Wyatt Earp, now a weary gunfighter, joins his brothers Morgan and Virgil to pursue their collective fortune in the thriving mining town of Tombstone. But Earp is forced to don a badge again and get help from his notorious pal Doc Holliday when a gang of renegade brigands and rustlers begins terrorizing the town.
When his sister Betsy packs up and leaves the family's Montana cattle ranch to find fame and fortune in Hollywood, her brother Jim decides to follow after her to make sure she doesn't get into trouble.
In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.
Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
Will Kane, the sheriff of a small town in New Mexico, learns a notorious outlaw he put in jail has been freed, and will be arriving on the noon train. Knowing the outlaw and his gang are coming to kill him, Kane is determined to stand his ground, so he attempts to gather a posse from among the local townspeople.
Marshall Jed Cooper survives a hanging, vowing revenge on the lynch mob that left him dangling. To carry out his oath for vengeance, he returns to his former job as a lawman. Before long, he's caught up with the nine men on his hit list and starts dispensing his own brand of Wild West justice.
A town—where everyone seems to be named Johnson—stands in the way of the railroad. In order to grab their land, robber baron Hedley Lamarr sends his henchmen to make life in the town unbearable. After the sheriff is killed, the town demands a new sheriff from the Governor, so Hedley convinces him to send the town the first black sheriff in the west.
Karukan, a ronin samurai, travels to the old west after his clan fails to stop a beast that has escaped Japan. He hires Langdon, to accompany him to stop the beast from killing.
Gangster Chandler and his accomplice Tracy arrive at a dude ranch. Cowboy Kentucky arrives at the same time. When Tracy double-crosses his boss and has the stage robbed, Kentucky finds the outlaws and brings them in. Tracy frames him for the murder of the driver but his pal Cactus gets him out of jail. He returns just as Chandler shoots Tracy and Kentucky finds himself arrested for another murder.
The Apache Indians have reluctantly agreed to settle on a US Government approved reservation. Not all the Apaches are able to adapt to the life of corn farmers. One in particular, Geronimo, is restless. Pushed over the edge by broken promises and necessary actions by the government, Geronimo and thirty or so other warriors form an attack team which humiliates the government by evading capture, while reclaiming what is rightfully theirs.