A cowhand and his sidekick come to the Texas border country looking for the man who had lured the cowhand's sister in bondage in Mexico. But the man doesn't want to be found and has hired some gunmen to see that he isn't.
Cheyenne has been ordered to take a vacation so Fuzzy has him go to a ranch of a friend. When they arrive at the El Lobo ranch, they find that his friend is dead and they want no visitors.
Major Bower’s wife tells her lover Chaliko where her father’s fortune is hidden. When the major finds out he murders her and with his gang, goes after Chaliko.
Ken Maynard's exceptionally intelligent horse, Tarzan the Wonder Horse, is the star of this western about evil cowboy Steve Frazer (Welch) who gathers horses for slaughter, whose meat is sold to pet food manufacturers. The wild horse Tarzan frees the doomed horses from their corrals, and Frazer convinces the Sheriff that Tarzan is a threat and can be shot on sight. Local cowboy Ken Benson (Maynard) and rancher Pat Riley (Kennedy) work together to clear Tarzan's good name and put Frazier behind bars for his evil deeds.
Shortly after Brand kills Gelbert, Tom Rayburn arrives on the scene and is accused of the murder. Escaping, he goes after Doc Mathews, the man that can prove his innocence. Brand is also after Mathews and intends to keep him from testifying. But Mathews is a ventriloquist and this will lead to Brand's downfall.
When the Sioux come to Canada, the Canadians permit them to stay in Canada if they come peacefully. However, some cowboys kill all inhabitants of one of their villages. The cowboys seek to get back their horses, but they pretend to search for a girl who once had been robbed by the Indians.
Bill Carson arrives and tells Cash Horton that his supposedly worthless mine contains valuable tungsten. Duke learns of the mine's value and tries to have them both killed. Failing, he has the Sheriff arrest Bill for murder. Unknown to Bill and the Sheriff, the victim is alive and well.
Trouble starts when Bill Larkins and his two sons move in with his brother Joe. They start rustling cattle and then kill Rod's father with Joe's gun. The Sheriff and Rod think they did it and are after proof.
Bob arrives looking for the killer of his uncle. When the Sheriff chases him and his partner Rusty, Reno thinks they are the men he is looking for and takes them into his gang. There Bob finds his uncle's gun and knows he has found the right gang. However he realizes the gang has an unknown leader and he sets out to find him.