The Old West. The end of the Frontier era. As civilization draws steadily nearer, the last remaining drifter finds himself trapped in the last of the brutal frontier towns. The catch - everyone in the town believes the drifted to be Destry, a notorious swindler who deserted the town in disgrace five years earlier.
Tiger Thompson promises a dying train robber to mind his innocent daughter and return the stolen loot. Along the way, Thompson is attacked by the dead man's gang but manages to reach the law (and the girl) in one piece and with the stolen money intact.
Neil Allison is tricked into assaying some false samples from a young crook's mine. When Neil sees that he has been duped, a quarrel ensues, and Jim Starke, the youth, is stabbed by an unknown assassin. Neil runs away thinking he has committed murder and becomes the unwitting partner of the victim's father.
Gracia, a half-breed Indian girl, plots with Cons Saunders to steal cattle from Blake because he is oblivious to her charms. With his stock gone, he cannot repay the money he owes his Uncle Benedict, and when Benedict is murdered, Blake is suspected. Because Blake has taken care of Saunders (Cons's father) for the many years he has been without the use of his legs, the latter is finally conscience-stricken and confesses to the crime, thus freeing Blake to marry Diana.
J. Wesley Pringle and S. S. Thorpe are running against each other for sheriff. Unscrupulous Thorpe has his gang kidnap Pringle to prevent his win but Georgie Hibler, the daughter of Pringle's biggest supporter and her good friend, Fite, whom Pringle had saved from suicide, team up to saves him from the gang. Pringle wins the election and the girl!
Gold miner Jim Golden is in love with Miss Dot, the local postmistress, but he has a reputation for being somewhat lazy and shiftless. One day he finds a baby that had been abandoned by local Indians, adopts it, and begins to work his claim again. Parky, a local thief and swindler, finds out that Jim has finally struck gold, and schemes to trick Jim out of his claim and kidnap Miss Dot while he's at it.
When Silent Sanderson's brother kills himself over the rejection of a woman, Silent blames Judith Benson and leaves the family homestead to begin a new life in Alaska. He is later reunited with Judith Benson, only to discover that his brother didn't commit suicide at all but was murdered by the woman's jealous husband.
Dolly Mainard, en route to her father, a major at Fort Blaine, is escorted through dangerous Sioux territory by a cavalry detachment and Army scout Jim Cardigan. When Captain Blackwell offends some braves of Chief Gray Wolf's tribe, Jim is sent ahead to the Indian camp to ask for peace. Imprisoned by the Indians, he sends a message to Blackwell not to advance; Donlin, a renegade scout, tears the note in such a way that the message is distorted, and the entire force is killed. When Jim escapes, he is accused of treason by Blackwell, court-martialed, and sentenced to death; however, he escapes and rescues Dolly, her father, and Blackwell from Donlin's band of renegades. Jim discovers the missing portion of the note in Donlin's hat, proving his innocence. Dolly remains to become his wife.
"The Wickedest Place in the World - Tourists Welcome", so says the banner across main street. Bill Scott rides into the city looking for adventure. At the Palace Hotel, the wickedest place in Satan Town, Sue of the Salvation Army strives to reach one or two of the drunks, gamblers, and prostitutes that throng the saloon. Malamute, the bouncer at the bar, never shies from a fight, and what's more, he's never lost one. Sue, to her misfortune, has gotten on his nerves.
Bob and Jim Whitely are twin brothers. Bob, an army veteran who suffered shell shock in the war, escapes from a sanitarium and holds up the Express train, for which Jim is mistakenly arrested. Jim soon escapes from jail in order to find his brother. However, his task is complicated by a crooked sheriff who pins a holdup and murder on him that the sheriff himself actually committed. To make matters worse, the murder victim was Tommy Wilkins, the brother of Jim's fiancee, who now thinks that Jim killed her brother.
Bruce McLeod returns from the goldfields to find that his wife has left home with another man, taking their child. After the death of the mother, the child is adopted by Cherie, a local dancehall girl ostracized by the community. Cullum, a gambler who earlier seduced Mrs. McLeod, drifts into the town, and failing to win Cherie, he swears vengeance. McLeod, seeking the man who wrecked his home, falls in love with Cherie but scorns her when he discovers that she is a dancer. Ultimately, the child identifies Cullum as the gambler who lured Mrs. McLeod from her home. In the ensuing fight, Cullum is shot by a halfbreed, and Bruce is happily united with Cherie.
The only key to a young woman's fortune lies in a marking on the leg of a horse called The Ghost of the Gauchos. But the woman's guardian, her uncle, plots to steal her wealth.
A boy's father is an unjustly accused fugitive, and the boy's scheming uncle plots to become the youngster's guardian and take over the family fortune.