Heavyweight boxing champion Jack Dempsey stars in this 15 chapter action serial, of which portions of reels 1, 2, and 4 survive. In the serial he plays the star fullback of his college's football team who gets drawn into an adventure when he stops to rescue a young woman from some thugs on a country road. It includes a gag featuring an exploding football. The rest of the cast includes Lon Chaney, Edgar Kennedy, Bull Montana, Josie Sedgwick and Herschel Mayall.
When his brother Dave is put in jail, Bill Hickok returns to help him. Dave has been charged with attempted murder when the other man drew first. Judge Barlow put him there and Bill gets the Judge to confess. Bill learns that Rance McKee is behind all the trouble and he forces the Judge into the decisions he wants. So Bill heads out by himself to face McKee in the showdown.
Jack Randall plays Dunham, a wandering cavalier who comes to the aid of frontier heiress Mary. The girl's legacy is half-ownership of a prosperous saloon, the other half controlled by hissable villain Slater. With the help of no less than two comic sidekicks, Dunham cuts the villain down to size.
Number 10 in Monogram's series of 24 "Range Busters" westerns, Crash Corrigan, Dusty King and Alibi Terhune, the Range Busters,enlist in Teddy Roosevelt's Rough Riders during the Spanish-American War, but are mustered out and sent to Wyoming to clean up a cattle-rustling situation that is affecting the Army's meat supply. Arriving in North Butte, Crash's home town, they all get separate jobs. Jane Blanchard, a reporter from the Denver Daily, also arrives in town in search of a story, and is posing as a waitress. They learn that Jeff Miller is behind the huge combine of rustlers, but Miller also learns that they are the Range Busters and are on his trail. He and his henchmen engage the out-numbered Crash and Alibi in a fight, but Dusty stampedes a large herd of Miller's stolen cattle into the midst of the fray.
Having briefly abandoned his standard "Nevada Jack McKenzie" characterization in Flame of the West, cowboy star Johnny Mack Brown was back as Nevada Jack in Monogram's The Lost Trail. Vowing to bring in a gang of stagecoach outlaws, Nevada redoubles his efforts when he learns that the owner of the stagecoach line is pretty Jane Burns (Jennifer Holt).
To fight a poisonous weed, ranchers are burning their land. Gene is the Inspector brought in and he recommends spraying. The spraying goes well until the Larabee ranch is reached. When Larrabee refuses to allow the equipment on his land, Gene has it sprayed by airplane. Cattle must stay off recently sprayed land and when a Larrabee man shoots down the plane, the crash sends the cattle stampeding toward the newly sprayed land.
Before changing his name to Richard Powers, cowboy hero Tom Keene spent the waning days of his stardom at Monogram, churning out westerns like Riding the Sunset Trail. When ingenue Betty Dawson (Betty Miles) and her kid sister Sugar (Sugar Dawn) are cheated out of their cattle ranch, Tom Sterling (Keene) and his sidekick Mendoza (Frank Yaconelli) vow to get the ranch back for the girls. This requires Sterling to cross six-guns with Pecos Dean (Gene Alcase), a former friend who'd turned bad.
The Harper wagon train is carrying money and Bull and his gang are after it. When their first attack is foiled by the rangers, Allen trails them. But he is captured and his ranger badge used to divert the rangers away leaving the wagon train unprotected.
A caravan of settlers is arriving and the ranchers intend to keep them out. It looks like a range war but Sheriff Jim gets the ranchers to accept the settlers. Kohler re-ignites the feud by making settler Winters appear to be a rustler and then by killing Winter's son. Once more the two sides appear headed for a war and Jim is caught in the middle.
O'Brien is "Whispering" Smith, so named because he speaks softly but knows how to fend for himself. The son of a railroad president, Smith is determined to learn the business from the ground up, so he gets a job as a track walker for his dad's rail line. While going about his duties, he meets Nan Roberts (Irene Ware), who is about to sell her Colorado ranch. Smith finds out that there are valuable tungsten deposits on her land and makes certain she won't be cheated by the villains
Tex and Ananias are sent by the government to capture some Santa Fe rustlers. Tex recognizes Hendricks as an outlaw, captures him and learns that Hendricks intends to meet a rustler named Dorgan. Tex goes instead and finds out that Dorgan plans to move rustled cattle through the ranch owned by Graham and his daughter Ruth. Dorgan has Graham Pass set to be dynamited to stop any pursuit.
When unscrupulous rodeo promoter Colonel Winthrop gets the idea of capturing "Outlaw" and making him a show horse, his niece Kay North tricks Monte into believing she is a writer assigned to do an article on the real horse.
A group of cowboys ending their cattle drive in Abilene find that cattle prices are being kept artificially low, driving down the price they'll get for their beef. They set out to change the situation.
A "special" by Monogram standards, Lure of the Wasteland was lensed in a not inexpensive process called Telco-color. Grant Withers takes a break from his duties in the "Mister Wong" series to play Smitty, a US marshal assigned to track down $250,000 in stolen bonds.