Carl Beldon has disappeared and the Trail Blazers have been sent to investigate. Arriving in town, they find that 'Honest John' controls everything. He even prints his own money. He also has a gang and they set out to finish off the heroes.
Gene Autry hunts bank robbers Al Bartlett and Trot Lucas with his old friend Mike. Bartlett, to throw off his pursuers, kills Trot and his own brother. When Kitty Bartlett comes to town claiming to be the slain Bartlett's widow, Gene has to save her from the irate townspeople who are not aware that her name isn't Bartlett but she really is the daughter of a law officer slain by Al Bartlett. Ben Luder, a local hood, tricks Bartlett back into town by saying he has to fixed to have Doc Larry Taylor do plastic surgery on him. En route they meet Doc and his assistant Helen Ellis and Ben's ruse is exposed. Bartlett kills Ben and forces Doc to drive him to the railroad. Gene, in a fight atop a runaway train, captures Bartlett.
President Lincoln personally sends Bill Gibson west to see if he can stop the holdups of the needed shipments of gold. There he meets his boyhood friend Foster. When all others refuse to take out the next gold shipment due to the killings, Bill volunteers. Jeannie, afraid for his safety, tells Foster of Bill's secret route not knowing Foster is the leader of the outlaw gang.
Native son returns from school in Spain to California in 1855 and finds corrupt politicians stealing land from old California families. He becomes a sort of Robin Hood in order to fight them.
Gene Autry becomes the new Sheriff after bank robbers kill the former sheriff. When Judge Beaumont is murdered, evidence points to the judge's wild son. Believing the young man, Gene tries to help.
A ranch owner fires his ranch hands and brings in women to replace them. The owner's daughter wants the male hands back and comes up with a plan to do it.
Jack rides into trouble when he meets up with Bill Meeker and his outlaw gang. Rescued from the gang's clutches by Don carlos, he joins forces with Carlos and with the help of Lolita who learns of the gang's next raid, they go after the culprits.
Canadian Mountie Mason is sent south of the border to look for a horse thief with only a watch chain for evidence. He befriends young Andy and when Calhoun hits Andy, Mason and Calhoun fight. In the scuffle Calhoun's watch with the missing chain is dislodged. Mason then sets out to bring in Calhoun and his gang.
The Cooper gang is terrorizing the town of Stanton with heinous crimes. When the gang rapes and murders an innocent young widow, the sheriff teams up with a notorious gunslinger, the brother of the murdered widow, in order to enact vengeance and justice. Because the lawman's and the gunfighter's methods are so different, two more innocent deaths occur, a friend of the sheriff and a lady friend of the gunfighter ...How will this end?
Montana ranch owner Cyrus Bigbee sends his foreman, Gene Autry, and Rawhide Buttram to his Canadian timber land to stop the marriage of his daughter Sandy to Todd Markey, whom he dislikes. Sandy wants to turn the property into a dude ranch, with Carolina Cotton and the Cass County Boys (Fred S. Martin, Jerry Scoggins and Bert Dodson) among the entertainers, and runs up against local timbermen who want it for cutting timber. When a Mountie is murdered, with suspicion pointing to Todd, Gene finds the real culprit and brings peace to the area.
Like 1940's Melody Ranch, the 1941 Gene Autry vehicle Down Mexico Way was designed as a "special", to be promoted separately from Autry's regular B-western series as an A-picture attraction. The story gets under way when a pair of con artists, Gibson (Sidney Blackmer) and Allen (Joe Sawyer), breeze into the town of Sage City claiming to be movie producers. The two scoundrels promise to film a movie in the little burg on the condition that the townsfolk pony up the necessary production fees.
After years in prison, a gang of criminals are deported from Bavaria and arrive as free immigrants to America. They kill an Indian by accident and do different jobs such as cleaning latrines, until they get installed in an abandoned house next to an Indian woman. One day someone will propose to perpetrate a robbery ...