The conflict between a railroader and a stage line owner is being aggravated by bad guys who are sabotaging both sides. Roy and Gabby mediate the conflict and expose the bad guys.
Lawyer Creech is after the ranch of the dying Cartwright. First he brings in Cahill to pose as the only living relative. Then when the Tonto Kid finds platinum on the ranch, Creech frames him for murder.
The Mesquiteers return to Texas after the Civil War to find Army carpetbaggers fighting the local bushwackers. They quickly learn that Capt. Hawks and his men are the culprits and join up with Morgan and his men.
Cattle are being routinely stolen from a local ranch, and suspicion centers on a local mountain family. But the Three Mesquiteers are wise to the criminals' deeds. But when a ranger is shot and Stony is framed for the crime, it's up to Lullaby and Tucson to prove his innocence.
Reporter Speed Morgan helps Flash Barrett escape from the police and this gets him into Flash's gang where he poses as a gangster. Flash and his gang head west guning for Bill Miller who failed to send some diamonds on to Flash. Speed hopes to bring Flash to justice but is in trouble when his true identity is revealed.
Two old drunks named Gin & Whiskey Joe, with their mules, engaged in a personal fight, find some gold nuggets in a river, they decide to look for the remaining ones through a map which they divide in half, gangs of bandits hear of the news and cast all suspicions on the holders of the map to two homosexual cowboys, who will seek refuge in a nunnery.
As foreman of a dude ranch, Gene has two problems. One is a guest, the spoiled daughter of a millioniare, and the other is the disgruntled ex-foreman that Gene replaced, now just a ranch hand. Gene eventually gets the daughter straightened out but has to fire the ex-foreman and this leads to trouble when he returns intent on revenge.
Ex-Pony Express rider Autry ties to protect his US mail franchise as the Pony Express gives way to stage coach mail and the telegraph. Gene's last film appearance as a singing cowboy.
While Sam Houston in in the nation's capital trying to get Texas into the Union, his aide is trying to impose a self-serving tax on the use of the Santa Fe trail. The lady owner of a wagon train is using the trail, and a Texas Ranger comes to her assistance.
Manzanita Springs ia a combination small airline and spa and Vance Brados wants it. He pays their mechanic to have the planes run out of fuel so his men can rob the gold shipments and kill the pilots. After Sheriff Roy Rogers catches the mechanic, Roy plans one more gold shipment to get proof and this time his men will be ready. But it looks like Roy's plan will fail when Brados suspects a trap and call off the raid.
James Craig is torn between his criminal career as the masked bandit named the "El Paso Kid," and the life of a law-abiding citizen with his long-suffering wife Zoe. He repeatedly tells Zoe, "just one more time," but he is unable to stop which angers her greatly. However, he does have brief moments of heroics such as when he helps the Widow Weeks save her farm.