Ranger Eddie Dean is looking for the outlaw the Tioga Kid, a man he closely resembles. He runs into Joe Morino and his gang of rustlers at the same time Tioga arrives to cut himself into Morino's game. But Morino doesn't give in and in the showdown, Eddie and the Kid find themselves on the same side.
In early spring of 1833, the smoldering resentment of American settlers in Texas against their oppression by Mexico dictator General Santa Anna/Ana coming to a head. When a decree is issued that no more Americans may enter Texas, William H. Wharton, fiery head of a faction determined on independence or nothing, warns Stephen F. Austin that the time for half-measures is past. Austin, responsible for bringing the Americans to Texas as colonists, reminds Wharton that a settler's revolt against Mexico would dishonor his name and the arrangements he had with the Mexican government. He gets the "Whartonites" to agree to a general convention of all colonists. Almerian Dickinson, biggest land owner in the settlement of Gonzales, deeply in love with his wife Anne, warns Wharton that a bloody revolt would endanger every wife and mother in the colony. He proposes they send Austin to Mexico City to ask Santa Anna to grant Texans a voice in their own government.
"Nevada" and "Weary" Pierce hijack the loot taken in a bank hold-up by Les Setter, and his gang. They escape from Sheriff Jim Henry Warner. U. S. government horse-buyer David Ward is killed by Settler's men and Settler takes his papers and goes to the ranch of Blaine and asks for the horses Ward was to buy, promising payment from the government later. He also takes an interest in Ina Blaine, much to the resentment of her sweetheart Ben Ide. "Nevada" and "Weary" are hired for the horse round-up but Setter has them and Ben arrested on a fake charge.
Harris and Rigby own a circus. Rigby is a counterfeiter and frames his partner. The Mesquiteers learn Rigby is the culprit and get a confession from one of his men only to lose the case when the man is murdered in jail. The Mesquiteers try again and send Lullaby to try and win some of the fake bills in a card game.
Lawyer Bowdre has started a war between the ranchers and the homesteaders planning to take over the homesteaders land when they are wiped out. Rancher Dan Stockton, having just married homesteader Gail Dawson, is caught in the middle. He suspects Bowdre is behind the war and it's not long before he gets a chance to prove it.
When Johnny and Mendez argue, the lights go out, and in the ensuing gunfight Johnny thinks he killed his friend Dick. Now refusing to wear a gun he crosses the border. But it is not long before he runs into Mendez and more trouble.
Brett runs a protection racket for an unknown boss. When Jeff Hayes arrives and opens a gambling den, they try to shut him down. Unlike the others who have given in, he plans to fight back.
Crooked ranch foreman Thatcher sends his two henchmen, Parnell and Clint, out to murder his boss, wealthy Peter Arnold who has just arrived to retire on his ranch, bringing in tow his daughter, tomboy Jessie, who despises western life and can't wait to run off back to San Francisco. Stagecoach line owner Dave Collins and his sidekick Chito show up just in time to deter the attackers. Collins isn't done yet, though, as a gold shipment sent on one of his stages is stolen by Parnell and Clint, one of whom is recognized by Jessie, attempting to escape back to the west coast. Collins has his hands full trying to retrieve the stolen gold, and dealing with Jessie, who's fallen head-over-heels in love with him.
When there is a drought on an Indian reservation, everyone is in desperate need of water so that they can quench their thirst, their crops can grow, the animals will provide them food, etc. But rather than having to wait for the rain to come the old-fashioned way, a weather pill pertaining to that is used to bring instant showers.
A wanted man out West pastes Woody's picture over his own wanted poster, and Calamity Jane goes after the reward. Woody outsmarts Jane, but she falls in love with the outlaw when she sees his ugly face.