Heading through Colorado Territory in search of gold and women, Alferd Packer and his group of bemused companions find themselves lost, starving and musically inspired by the obstacles they confront along the way, including a die-hard Confederate cyclops, a trio of surly trappers, a tribe of Japanese-speaking "Indians," and ultimately, each other.
A scruffy garbage boy becomes the pupil of famed gunfighter Talby, and the stage for confrontation is set when the gunman overruns the boy's town through violence and corruption.
On the way to pick up the bounty on a wanted murderer, a bounty hunter stops at a staging post where he is forced to continue his journey with two outlaws who want the murderer for their own reasons and a recently-widowed woman, with the murderer's brother and his men in hot pursuit.
Soon after a newlywed learns that her husband had her father shot down, she flees from the Callahan ranch in fear. She's rescued by a gunman who safeguards her at a remote outpost as he staves off her husband's attempts to reclaim his bride.
With little luck at keeping a job in the city a New Yorker tries work in the country and eventually finds his way leading a herd of cattle to the West Coast.
Arizona Territorial Prison inmate Paris Pitman, Jr. is a schemer, a charmer, and quite popular among his fellow convicts — especially with $500,000 in stolen loot hidden away and a plan to escape and recover it. New warden Woodward Lopeman has other ideas about Pitman. Each man will have the tables turned on him.
An authoritarian rancher rules an Arizona county with her private posse of hired guns. When a new Marshall arrives to set things straight, the cattle queen finds herself falling for the avowedly non-violent lawman. Both have itchy-fingered brothers, a female gunman enters the picture, and things go desperately wrong.
Two miners agree to guide a mysterious woman, who has appeared in their camp from nowhere, to a nearby town; but soon, because of her erratic behavior, they begin to suspect that her true purpose is quite different.
Detective Matthias Breecher, hired to track down the worst of the Confederate war criminals, roams the Old West seeking justice. His resolve is tested when he meets a determined pioneer woman who is far more than she seems.
Notorious shootist and womanizer Quirt Evans' horse collapses as he passes a Quaker family's home. Quirt has been wounded, and the kindly family takes him in to nurse him back to health against the advice of others. The handsome Evans quickly attracts the affections of their beautiful daughter, Penelope. He develops an affection for the family and their faith, but his troubled past follows him.
At the beginning of the 20th century, a newspaper organizes an endurance horse race : 700 miles to run in a few days. 9 adventurers are competing, among them a woman, Miss Jones, a Mexican, an Englishman, a young cow-boy, an old one and two friends, Sam Clayton and Luke Matthews. All those individualists will learn to respect each other.
Forester, a ruthless oil baron, wants to create a war between the native American tribes and the white men. Old Shatterhand, Winnetou and their sidekick Castlepool try to prevent this.
Drifter Cole Harden is accused of stealing a horse and faces hanging by self-appointed Judge Roy Bean, but Harden manages to talk his way out of it by claiming to be a friend of stage star Lillie Langtry, with whom the judge is obsessed, even though he has never met her. Tensions rise when Harden comes to the defense of a group of struggling homesteaders who Judge Bean is trying to drive away.
A man in search of revenge infiltrates a ranch, hidden in an inhospitable region, where its owner, Altar Keane, gives shelter to outlaws fleeing from the law in exchange for a price.
Arms dealer Yolaf Peterson aims to make a sale to guerilla Mongo, but the money is locked in a bank safe, the combination known only to Professor Xantos, a prisoner of the Americans. Yolaf agrees to free Xantos, accompanied by reluctant guerilla Basco, but a former business partner of Yolaf's- John 'The Wooden Hand', has other ideas.
Blaise Starrett is a rancher at odds with homesteaders when outlaws hold up the small town. The outlaws are held in check only by their notorious leader, but he is diagnosed with a fatal wound and the town is a powder keg waiting to blow.
After the 1860s Wild West, a group of misfit settlers - including ex-doctor Phil Taylor, prostitute Belle, and homosexual bookseller Julian - decide they cannot live in their current situation in the west. They hire a grizzled alcoholic wagon master by the name of James Harlow to take them on a journey back to their hometowns in the East.