Bandits lead by Matt the Mute enter a bar and kill multiple people. Randy Bowers comes to town and is framed by Matt the Mute, who is working with the sheriff (who doesn't know Matt is really a criminal). Randy escapes with the help of the niece of the dead owner of the bar. Bowers ends up running from the sheriff, and ends up in the cave in which the bandits have their hide-out…
When John Mason's father is killed, John is wounded. Attracted to his nurse Alice, a conflict arises between him and his friend Ben who plans to marry Alice. John later finds the killer of his father but goes to face him not knowing Ben has removed the bullets from his gun.
Rodeo star John Scott and his gambler friend Kansas Charlie are wrongly accused of armed robbery. They leave town as fast as they can to go looking for their own suspects in Poker City.
Tobin is after the bandit Zanti who killed his parents. He finds him just as Zanti is about to kill Dusty and kidnap Ruby. Saving the two, he goes after Zanti. He catches him but Zanti escapes the Sheriff's handcuff's and this time Tobin has to chase him into the desert.
James Kincaid controls the local water supply and plans to do away with the other ranchers. Government agent Sandy Saunders arrives undercover to investigate Kincaid's land swindle scheme, and win the heart of one of his victims, Fay Denton.
Jerry Mason, a young Texan, and Jake Benson, an old rancher, become partners and strike it rich with a gold mine. They then find their lives complicated by bad guys and a woman.
The Marshal sends John Weston to a rodeo to see if he can find out who is killing the rodeo riders who are about to win the prize money. Barton has organized the rodeo and plans to leave with all the prize money put up by the townspeople. When it appears that Weston will beat Barton's rider, he has his men prepare the same fate for him that befell the other riders.
Audie Murphy comes into his own as a Western star in this story. Wrongly accused by crooked railroad officials of aiding a train heist by his old friends the Daltons, he joins their gang and becomes an active participant in other robberies. Betrayed by a fellow gang member, Murphy becomes a fugitive in the end. Seeking refuge at the ranch of a reformed gang member, he hopes to flee with the man's daughter to South America, but he's captured in the end and led off to jail. The girl promises to wait.
John Wyatt is a government agent sent to smash a counterfeiting operation near the Mexican border. Joining Doc Carter's medicine show they arrive in the town where Curly Joe, who once framed Carter, resides.
After being released from prison, ex-gunfighter John Wesley Hardin hopes to have his autobiography published in order to rehabilitate his tarnished reputation.
In Wyoming, mountain trapper Yancey goes to the nearest town to trade his pelts but gets into trouble when he tries to save runaway dance-hall girl Rosalie from her shameful job.
After robbing a bank Murphy assumes the identity of his pursuer, a famous US Marshal, when he stumbles into a town and is confronted by the local judge, Matthau. Murphy is forced to remain as the new Marshal; an old flame, Scala, nearly unmasks him by accident, only to be forced to assume the ruse of being Murphy's wife. The "couple" given a house and respectability, which neither has had before. They maintain the charade to avoid hurting a young orphan boy, Matthau's ward. Scala is torn by her loyalty to boyfriend planning to rob the bank and growing feelings for Murphy
A Confederate officer travels to a wild Mexican border town to buy guns, aiming to keep up the fight against the Yankees - but who can he trust in this lawless place?
White settlers plan to defy the agreement between the government and the Comanche to mine for silver on Comanche lands, while scout Jim Bowie tries to keep the peace in the territory.
Jim Harvey is hired to guard a small wagon train as it makes its way west. The train is attacked by Indians and Harvey, hoping to persuade Aguila, the chief, to call off the attack due to Harvey's having saved his son's life, leaves the train to negotiate. He is captured and the rest of the train is wiped out except for two sisters. Escaping and showing up in town later, Harvey is nearly hanged as a deserter, but gets away. Eventually caught by the sheriff and his posse, they are attacked by Indians. This time the Indians are defeated and Aguila, captured and dying, reveals the identity of the white man who engineered the initial attack on the wagon train, just as the perpetrator rides up behind them.