With little luck at keeping a job in the city a New Yorker tries work in the country and eventually finds his way leading a herd of cattle to the West Coast.
Following the surrender of Geronimo, Massai, the last Apache warrior is captured and scheduled for transportation to a Florida reservation. On the way he manages to escape and heads for his homeland to win back his girl and settle down to grow crops. His pursuers have other ideas though.
In this strange western version of Moby Dick, Wild Bill Hickok hunts a white buffalo he has seen in a dream. Hickok moves through a variety of uniquely authentic western locations - dim, filthy, makeshift taverns; freezing, slaughterhouse-like frontier towns and beautifully desolate high country - before improbably teaming up with a young Crazy Horse to pursue the creature.
By his dying father's last wish Joe is sent to the Wild West to become a real guy. The dreamy young man despises guns and fights likes poems and prefers bicycles to horses. Now his three teachers footpads all of them shall teach him otherwise. This doesn't work until Joe has to defend himself against gunman Morton who's jealous of Joe's love to rancher Ohlsen's beautiful daughter.
El Chuncho's bandits rob arms from a train, intending to sell the weapons to Elias' revolutionaries. They are helped by one of the passengers, Bill Tate, and allow him to join them, unware of his true intentions.
Arizona Territorial Prison inmate Paris Pitman, Jr. is a schemer, a charmer, and quite popular among his fellow convicts — especially with $500,000 in stolen loot hidden away and a plan to escape and recover it. New warden Woodward Lopeman has other ideas about Pitman. Each man will have the tables turned on him.
An authoritarian rancher rules an Arizona county with her private posse of hired guns. When a new Marshall arrives to set things straight, the cattle queen finds herself falling for the avowedly non-violent lawman. Both have itchy-fingered brothers, a female gunman enters the picture, and things go desperately wrong.
Two miners agree to guide a mysterious woman, who has appeared in their camp from nowhere, to a nearby town; but soon, because of her erratic behavior, they begin to suspect that her true purpose is quite different.
After the Civil War, ex-Union Colonel John Henry Thomas and ex-Confederate Colonel James Langdon are leading two disparate groups of people through strife-torn Mexico. John Henry and company are bringing horses to the unpopular Mexican government for $35 a head while Langdon is leading a contingent of displaced southerners, who are looking for a new life in Mexico after losing their property to carpetbaggers. The two men are eventually forced to mend their differences in order to fight off both bandits and revolutionaries, as they try to lead their friends and kin to safety.
Detective Matthias Breecher, hired to track down the worst of the Confederate war criminals, roams the Old West seeking justice. His resolve is tested when he meets a determined pioneer woman who is far more than she seems.
When Letty Mason relocates to West Texas, she finds herself unsettled by the ever-present wind and sand. Arriving at her new home at the ranch of her cousin, Beverly, she receives a surprisingly cold welcome from his wife, Cora. Soon tensions in the family and unwanted attention from a trio of suitors leave Letty increasingly disturbed.
While passing through the town of Bannock, a bunch of drunken cattlemen go overboard with their celebrating and accidentally kill an old man with a stray shot. They return home to Sabbath unaware of his death. Bannock lawman Jered Maddox later arrives there to arrest everyone involved on a charge of murder. Sabbath is run by land baron Vince Bronson, a benevolent despot, who, upon hearing of the death, offers restitution for the incident.
Notorious shootist and womanizer Quirt Evans' horse collapses as he passes a Quaker family's home. Quirt has been wounded, and the kindly family takes him in to nurse him back to health against the advice of others. The handsome Evans quickly attracts the affections of their beautiful daughter, Penelope. He develops an affection for the family and their faith, but his troubled past follows him.
Howard Spence has seen better days. Once a big Western movie star, he now drowns his disgust for his selfish and failed life with alcohol, drugs and young women. If he were to die now, nobody would shed a tear over him, that's the sad truth. Until one day Howard learns that he might have a child somewhere out there...
Several pillars of society have robbed an Army safe containing $100,000 so they can buy the land upon which the coming railroad will be built. But they haven't reckoned on the presence of the master gunslinger, Sabata.
In Apache territory, a supply Army column heads for the next fort, an ex-scout searches for the killer of his Native wife, and a housewife abandons her husband to rejoin her Apache lover's tribe.
Forced to trade his valuable furs for a well-educated escaped slave, a rugged trapper vows to recover the pelts from the Indians and later the renegades that killed them.
Arms dealer Yolaf Peterson aims to make a sale to guerilla Mongo, but the money is locked in a bank safe, the combination known only to Professor Xantos, a prisoner of the Americans. Yolaf agrees to free Xantos, accompanied by reluctant guerilla Basco, but a former business partner of Yolaf's- John 'The Wooden Hand', has other ideas.