Several pillars of society have robbed an Army safe containing $100,000 so they can buy the land upon which the coming railroad will be built. But they haven't reckoned on the presence of the master gunslinger, Sabata.
The story follows General George Armstrong Custer's adventures from his West Point days to his death. He defies orders during the Civil War, trains the 7th Cavalry, appeases Chief Crazy Horse and later engages in bloody battle with the Sioux nation.
A white man trades with the Comanche for the release of a female stranger and the pair cross paths with three outlaws who have their eyes on the handsome reward for bringing her home and Comanche on the warpath.
Forced to trade his valuable furs for a well-educated escaped slave, a rugged trapper vows to recover the pelts from the Indians and later the renegades that killed them.
The story opens in a Western saloon, where a young musician with a banjo begins to tell a tale of Lucky Luke and his sworn enemies the Dalton brothers: Joe, William, Jack and Averell. Luke has, once again, as he has done many times before, thrown the four outlaws into jail. The prison is also the abode of a guard dog named Rin Tin Can (Rantanplan in the original French language version).
When a crooked sheriff murders his employer, William "Billy the Kid" Bonney decides to avenge the death by killing the man responsible, throwing the lives of everyone around him into turmoil, and endangering the General Amnesty set up by Governor Wallace to bring peace to the New Mexico Territory.
In Apache territory, a supply Army column heads for the next fort, an ex-scout searches for the killer of his Native wife, and a housewife abandons her husband to rejoin her Apache lover's tribe.
When the members of a caravan of pioneers find a daisy growing in the middle of the desert they decide to stop there and to build their town on this very spot. Houses soon spring up like mushrooms, immediately followed by a bank, a saloon, a prison, etc. Daisy Town is born. Unfortunately a city does not go without its bad boys and the peaceful place is soon turned into a lawless place. To restore law and order, a lawman is needed. Lucky Luke, the cowboy who shoots faster than his shadow, will be this man: all the villains had better watch out!
Will Penny, an aging cowpoke, takes a job on a ranch which requires him to ride the line of the property looking for trespassers or, worse, squatters. He finds that his cabin in the high mountains has been appropriated by a woman whose guide to Oregon has deserted her and her son. Too ashamed to kick mother and child out just as the bitter winter of the mountains sets in, he agrees to share the cabin until the spring thaw. But it isn't just the snow that slowly thaws; the lonely man and woman soon forget their mutual hostility and start developing a deep love for one another.
Arms dealer Yolaf Peterson aims to make a sale to guerilla Mongo, but the money is locked in a bank safe, the combination known only to Professor Xantos, a prisoner of the Americans. Yolaf agrees to free Xantos, accompanied by reluctant guerilla Basco, but a former business partner of Yolaf's- John 'The Wooden Hand', has other ideas.
So goes to the U.S. to open a martial arts school. Around this time, many Chinese people were sold off to U.S. railroad companies, and were brutally treated by the Americans under the harsh working conditions. Thus, the American workers' hatred towards the Chinese immigrants is high. As a result, So gets into trouble with the Americans and the mob, and calls Master Wong for help.
When half-breed Indian Yaqui Joe robs an Arizona bank, he is pursued by dogged lawman Lyedecker. Fleeing to Mexico, Joe is imprisoned by General Verdugo, who is waging a war against the Yaqui Indians. When Lyedecker attempts to intervene, he is thrown into prison as well. Working together, the two escape and take refuge in the hills, where Lyedecker meets beautiful Yaqui freedom fighter Sarita and begins to question his allegiances.
When Quintero, a Mexican revolutionary leader, is left to rot in jail by the forces of President Diaz, it's up to his subordinate, Max, to bust him out. With $600 in hand, he crosses the border into America and hires Chris Adams, a mercenary of considerable skill, who uses the rest of the cash on more hired guns. After the team is rounded out by experts on close-combat fighting, explosives, and knife-throwing, they set off to free Quintero.
A prospector sells his wife and daughter to another gold miner for the rights to a gold mine. Twenty years later, the prospector is a wealthy man who owns much of the old west town named Kingdom Come. But changes are brewing and his past is coming back to haunt him. A surveyor and his crew scouts the town as a location for a new railroad line and a young woman suddenly appears in the town and is evidently the man's daughter.
After the 1860s Wild West, a group of misfit settlers - including ex-doctor Phil Taylor, prostitute Belle, and homosexual bookseller Julian - decide they cannot live in their current situation in the west. They hire a grizzled alcoholic wagon master by the name of James Harlow to take them on a journey back to their hometowns in the East.