The feature length version of the serial by the same name. A mystical medicine arrow, the key to a lost gold treasure, is lost in one of many Indian attacks. It is recovered by the only two survivors, a Major and his daughter, who become the targets of those who wish to possess it. General George Armstrong Custer and army scout Kid Cardigan attempt to stop the ensuing war over the arrow, but fail in their efforts, which becomes the historic Custer's Last Stand.
Chet Kasedon is after the Indians hidden gold mine but Chief Moya will not reveal it's location. He has also hired mining engineers Gale and Mortimer to locate the mine. When Gale sees Kasedon's cruelty to Moya, he switches sides.
Bolton has organized a feud between the Rork's and the O'Neil's. He has rustled cattle and killed a man putting the blame on Danny O'Neil. Tom Rork has found a bullet with markings on it that he hopes will clear Danny and bring in the real killer.
Although Larry "Buster" Crabbe earns top billing, the hero of Drift Fence is former Western star Tom Keene as Jim Travis, who, at a rodeo, meets city dweller Jim Traft, who has come west to erect a fence that will prevent Clay Jackson from continuing his cattle rustling business. A tough Western type, Travis suggests that he impersonate Traft and the building of the fence soon begins. But Travis is opposed by Slinger Dunn and his family, whose small ranch will suffer from the division of the land. A romance between Travis and Slinger's sister, Paula, paves the way for a meeting of the minds, however, and Slinger switches sides completely upon learning that Travis is a Texas Ranger in disguise.
A miner who was swindled out of his mine by a banker turns to robbing stagecoaches. Several years after he is tracked down and killed, his son comes to town to tangle with the banker.
Kirk Baxter has been sent to investigate murder and robbery involving gold shipments. Identifying a gang member by his bullets, he uses that man's horse to locate and join the gang. He learns the gang is tipped off to the shipments by a mine employee using carrier pigeons. But the next message reveals his true identity and he is made a prisoner.
Rigging a horse race, Don Carlos wins a lot of money. When he loses his winnings at the gambling table, he shoots the dealer with Horton's gun. Horton is arrested but cannot prove his innocence.
Before he was murdered Grandpa Martin found a gold mine. He failed to record it and now everyone is looking for Martin's old horse that can lead them to it. When under-cover Texas Ranger Autry arrives to investigate, he is accused of the murder and finds the Sheriff after him.
A half Mexican, half Irish gunman called The Irish Gringo and his pals come across a little girl wandering in the desert. It turns out her grandfather was murdered by a gang looking for the Lost Dutchman mine, a map of which is drawn on the shirt she is wearing, and now the outlaws are after her.
Lawyer Rontel has made Geologist Sheffield his prisoner and by power of attorney is using his money to buy the ranches of those driven off by his hired men. But when he goes after Hayden, Tucson and Stoney arrive and things begin to change.
When his young son is shot, John Wellington kills the culprit and flees. But his son Johnny recovers and is raised by Sir George. Some twenty years later Johnny sets out to find Sir George's missing granddaughter.
Sheriff John Higgins quits and goes into prospecting after he thinks he has killed his best friend in shooting it out with robbers. He encounters his dead buddy's sister and helps her run her ranch. Then she finds out about his past.