Sam Burton's second wife is a Kiowa, and their son is therefore born mixed-race. When a struggle starts between the whites and the native Kiowas, the Burton family is split between loyalties.
The film tells the story of two twins separated in childhood who reunite when they are older. One of them has grown between outlaws and has become one of them, a murderous bandit who frightens the region. The other has grown, without knowing it, in exactly the ranch of the man who murdered his father and has become the loving foreman of the farmer's daughter, now deceased.
A Union Cavalry outfit is sent behind confederate lines in strength to destroy a rail supply center. Along with them is sent a doctor who causes instant antipathy between him and the commander. The secret plan for the mission is overheard by a southern belle who must be taken along to assure her silence.
Seeking a new place to call home, former Confederate soldier Ben Lassiter (Victor Mature) and his daughter meet Beth (Elaine Stewart), whose fiancé is a Union soldier. Lassiter falls for Beth, and when Indians attack, they head to a cavalry camp where Lassiter must battle the Indians as well as Beth's fiancé.
English gunsmith Jonathon Tibbs travels to the American West in the 1880s to sell firearms to the locals. He inadvertently acquires a reputation of quickness on the draw due to his wrist mounted Derringer style weapon. Soon gaining the post of sheriff, he endeavours to clean up the town using what skills he has—and by multilateral diplomacy.
Pat Garrett arrives in Abilene where he catches five of Butch Cassidy's gang. He calls in Wyatt Earp and Bat Masterson and they learn there is a half million dollar shipment of money arriving by train and Cassidy is amassing enough men to take it.
Searching for a doctor who can help him get his son to speak again--the boy hadn't uttered a word since he saw his mother die in the fire that burned down the family home--a Confederate veteran finds himself facing a 30-day jail sentence when he's unfairly accused of starting a brawl in a small town. A local woman pays his fine, providing that he works it off on her ranch. He soon finds himself involved in the woman's struggle to keep her ranch from a local landowner who wants it--and whose sons were responsible for the man being framed for the fight.
Heading east to Fort Worth to hire a schoolteacher for his frontier town home, Link Jones is stranded with singer Billie Ellis and gambler Sam Beasley when their train is held up. For shelter, Jones leads them to his nearby former home, where he was brought up an outlaw. Finding the gang still living in the shack, Jones pretends to be ready to return to a life crime.
Jake Wade breaks Clint Hollister out of jail to pay off an old debt, though it's clear there is some pretty deep hostility between them. They part, and Jake returns to his small-town marshal's job and his fiancée only to find he has been tracked there by Hollister. It seems they were once in a gang together and Jake knows where the proceeds of a bank hold-up are hidden. Hollister and his sidekicks make off into the hills, taking along the trussed-up marshal and his kidnapped bride-to-be to force the lawman to show them where the loot is.
After deceitful Indian agent Grat Bandas has his men shoot Brother Van, gunfighter Linc Prescott saves the peaceful circuit rider and agrees to help him put a stop to Bandas's plans to start an Indian war and grab their land for himself. Meanwhile, Prescott takes a shine to the daughter of a local rancher.
Lawman Wyatt Earp and outlaw Doc Holliday form an unlikely alliance which culminates in their participation in the legendary Gunfight at the O.K. Corral.
Frontier peacekeeper Sheriff Galt faces a crisis of conscience in The Iron Sheriff. In the aftermath of a robbery-murder, Galt follows the trail of evidence directly to his own son, Benjie. Sworn to uphold the law at all costs, Galt is grimly determined to see that Benjie will receive a fair trial without any coercion on his part. But the townsfolk have already decided that the sheriff will try to spring the boy, and a lynch-mob mentality slows festers its way through the community. As the trial proceeds, it becomes obvious that Benjie is going to hang for his alleged crime, but there's still one or two surprises in store.
New ranch owner Frank Madden, half Indian but posing as white, arrives just as an all white jury finds the three white Shipley brothers who lynched three Indians innocent. There is soon trouble between Frank and the Shipleys who are using Frank's land to graze their cattle. When the brother of one of the Indian victims kills a Shipley, Frank is accused and put in jail. The Shipleys then organize a lynch mob and head for the jail.
Daniel Boone leads settlers into Kentucky, but must battle Shawnee Indians who have been persuaded by a French renegade that Boone and the settlers are there to kill them and steal their land.