Grant hides stolen money in the luggage of Bonnie Shea who is moving west. Later when he and his men arrive to retrieve the money, they also kidnap Bonnie. This sends Reasonin' Bates and his cowhands on their horses after the gangsters in their cars.
A mining engineer teams up with a crusty deputy sheriff to solve the mystery killings at an old mine where the owner's family waits for him to die, and where a valuable radium strike may have been made.
A landslide has diverted water from the Baldwin ranch to Cambert's. With their cattle dying, Cambert refuses to let them have any water. Easterner Larry Knight takes a job with the Baldwins and he has a plan to divert the water back to the Baldwin ranch. But Phil, jealous of Kitty's attraction to Larry, lets Cambert know of the scheme.
Jack rides into trouble when he meets up with Bill Meeker and his outlaw gang. Rescued from the gang's clutches by Don carlos, he joins forces with Carlos and with the help of Lolita who learns of the gang's next raid, they go after the culprits.
Chris Morrell, the guardian of half-Indian girl Nina, is helping her find her missing white father. so she can cash in on her late mother's oil lease. Outlaw Sam Black is after the girl and her father as well. Besides dealing with the Black gang, Morrell has to find another robber, Jim Moore, who switches clothes with him after he finds Chris unconscious from a fight with Sam Black. Along the way, he meets a lady who's the sister of Jim Moore, another bad hombre who's in cahoots with Jim Moore, and an old friend who takes in Nina and helps Chris locate Nina's father and fight off the various desperadoes
Tobin is after the bandit Zanti who killed his parents. He finds him just as Zanti is about to kill Dusty and kidnap Ruby. Saving the two, he goes after Zanti. He catches him but Zanti escapes the Sheriff's handcuff's and this time Tobin has to chase him into the desert.
Gangster Chandler and his accomplice Tracy arrive at a dude ranch. Cowboy Kentucky arrives at the same time. When Tracy double-crosses his boss and has the stage robbed, Kentucky finds the outlaws and brings them in. Tracy frames him for the murder of the driver but his pal Cactus gets him out of jail. He returns just as Chandler shoots Tracy and Kentucky finds himself arrested for another murder.
Henry Jethrow is after the Wilson ranch. He has George Wilson unknowningly sign a note for the ranch, has him killed, and then presents the note. The Pinto Kid, investigating cattle rustlers, accidentally drops his glove at the murder scene and now has a price on his head. He has Beth Wilson turn him and use the reward money to reclaim the note. Now he has to escape jail and find the real killers.
An Easterner Inherits a cattle ranch, only to discover that thousands of cattle have been stolen. He secretly signs on as a hired hand at his own ranch to discover who's stealing them.
A wagon train heads west from Independence, Mo., along the Oregon Trail, led by proud cowboy Clint Belmet. On board are feisty young widow Nancy Wellington and her toddler, Sonny, as well as the older Abby Masters, who begins a romance with scout Jim Burch. Along the way, the wagon train battles Indians led by Kenneth Murdock, a trapper who doesn't welcome competition for Oregon's lucrative fur trade. Wagon Wheels is a 1934 remake of 1931's Fighting Caravans, using stock footage from the original.
Dyer is buying ranches and then retrieving his check by having his gang kill the owner. Bob Worth arrives just as Buck Morton is killed and gets blamed for the murder. Fleeing from the Sheriff, Bob teams up with the Mexican outlaw Golinda. Having seen Dyer pay off his men, he has a plan to trap him and Golinda is just the man he needs to make it work.
Bandits lead by Matt the Mute enter a bar and kill multiple people. Randy Bowers comes to town and is framed by Matt the Mute, who is working with the sheriff (who doesn't know Matt is really a criminal). Randy escapes with the help of the niece of the dead owner of the bar. Bowers ends up running from the sheriff, and ends up in the cave in which the bandits have their hide-out…
The Marshal sends John Weston to a rodeo to see if he can find out who is killing the rodeo riders who are about to win the prize money. Barton has organized the rodeo and plans to leave with all the prize money put up by the townspeople. When it appears that Weston will beat Barton's rider, he has his men prepare the same fate for him that befell the other riders.
When Sheriff Jake sees a man at the safe and then finds the payroll gone, he trails him. Just as he is about to arrest him, the man saves his life. Still suspicious, he joins up with the man and later they learn that Melgrove, the towns leading citizen, is trying to take over the area's ranches by having his gang stop all incoming supply wagons. With the ranchers about to sell to Melgrove, the two newcomers say they will bring in provisions.
When attacked by two dogs, Joe Gilmore leaves them on the desert to die. Later one of the dogs saves John Blake from drowning. Men arrive claiming the dog is killing their chickens. They want to kill the dog but John convinces them the dog's fate should be determined by a trial.
A stray German shepherd, a runaway teenage boy, and a runaway teenage girl end up at her uncle's place in Oregon, where an epidemic of sheep rustling is under way.