San Antonio Rose is an amiably wacky mini-musical evenly divided between its "official" stars, The Merry Macs, and a strong cast of supporting clowns. Robert Paige plays roadhouse operator Con Conway, whose establishment is in danger of being squeezed out by its competition. Stranded entertainers Hope Holloway (Jane Frazee) and Gabby Trent (Eve Arden) decide to revivify Conway's establishment by staging an energetic floor show built around the talented Merry Macs. A rival club owner dispatches his two top hooligans Jigsaw Kennedy (Lon Chaney Jr.) and Benny the Bounce (Shemp Howard) to wreck Conway's club by posing as waiters, but the two stupes are easily cowed into submission--by the leading ladies!
The conflict between a railroader and a stage line owner is being aggravated by bad guys who are sabotaging both sides. Roy and Gabby mediate the conflict and expose the bad guys.
Whopper, Stan Bradford, and Smokey are delivering a herd of pack horses to telegraph lineman Jeff Corbin when intercepted by smooth-talking Cobb Wayne, who is in a deadly competition with Corbin.
Bugs Bunny is hunted by Hiawatha, a stereotyped Native American who fills roughly the same role as Elmer Fudd in other Bugs Bunny cartoons of this era.
The notorious outlaw Black Bart has reappeared and the Range Busters are sent to investigate. When they find that Black Bart is now a respectable citizen and that someone is impersonating him, they set a trap for the robber.
Billy Bonney is a hot-headed gunslinger who narrowly skirts a life of crime by being befriended and hired by a peaceful rancher, Eric Keating. When Keating is killed, Billy seeks revenge on the men who killed him, even if it means opposing his friend, Marshal Jim Sherwood.
Bantam-weight western star Don "Red" Barry certainly deserved his designation as "The Cowboy Cagney" in Republic's Desert Bandit. Barry is cast as two-fisted Texas Ranger Bob Crandall, who after being dishonorably discharged heads to the Mexican border to start life anew. He falls in with a gang of gun runners, headed by corrupt lawman Largo (William Haade). It turns out, of course, that Crandall's "disgrace" was merely a ruse to allow him to work undercover in bringing Largo and his minions to justice.
Hoppy, Lucky and California search for a mine owned by Trudy Pendleton after it was taken from her by thw swindling gambler Ace Gibson. They find the mine and Hoppy fights Gibson over it.
Tom and Fuzzy investigate a ghost town which, in this case, is supposedly haunted by real ghosts. The town is an outlaw gang's hideout, and they scare folks away to protect their mine.
The Three Mesquiteers, as army scouts, soothe hostilities between the Army and Indians after both have been riled by someone with a hidden agenda - a renegade chief, who is found to be masquerading as an Army interpreter.
The mayor has sent for a gunslinger who, though appearing to clean up the town, is really to be the mayor's means of taking the town over. When Roy and Gabby arrive in Tombstone, Roy is mistaken for the gunslinger. Just as Roy is ready to expose the mayor, the real gunslinger shows up.
Tim MacGregor, unscrupulous lumber operator, obtains by bribery a contract to cut a vast quantity of timber from land owned by Kay Handley, rich débutante. When Dick O'Hara, forestry inspector, demands a postponement, MacGrgeor refuses and sends his henchman, Jean Collet, to obtain the services of the famous "bull-of-the-woods" Andy Jensen and his partner "Lucky." Kay arrives and gives her permission to cut the timber, defying Dick. Dick, with his two assistants, Withers and "Tex," begins a survey of the timber stand. When Dick and Tex finally reveal MacGrgeor as a crook, Collet is sent to kill "Tex" and obtain the reports. A fight ensues and "Lucky" is killed by one of Collet's flying knives. Kay then admits that Dick is right and helps him trap Collet. Dick and Andy force a confession from Collet and MacGregor is exposed.
Rancher Timothy Wade is ambushed by a masked man riding a pinto horse. His young son, Buzzy Wade and the loyal ranch foreman, Dude Bates, are mystified as to who anyone would kill Wade. But, Jim Dana, a U.S. government undercover agent, has his suspicions that the reason may have been in order to acquire the ranch from Buzzy and his older sister, Ruth. Dana thinks the ranch may have a large deposit of a mineral useful to a foreign country. His suspicions are confirmed when a couple of guys with heavy-accents show up inquiring about the property.