Bill Crane is a fun-loving cowboy who likes to play pranks with an Australian bull-whip, much to the dismay of his ranch-owning uncle, Pete Perry. Bill and his cousin, Jack Perry, compete for the affections of Mary Pinkleby. Jack, unknown to Bill, is also an outlaw gang-leader, known as Poncho. The latter frames Bill as being the gang leader, and now Bill has to elude the sheriff and also prove his own innocence.
Cliff Barton, suspicious of the intentions of the local banker, Seth Tolliver, withdraws his money from the bank, hides it, and is later killed by two hirelings of the banker. Deputy Sheriff Art Stratton, who has trained Barton's horse and is in love with his daughter, Thora, is assigned to guard the ranch for the creditors; and Tolliver, who has designs on the property and wants his son to marry Thora, arranges to have the ranch auctioned.
A Man Four-Square is a screen version of William McLeod Raine's popular tale of a rancher who finds himself falsely accused of murder while attempting to help a friend in need.
When Click's father is killed by a phantom bullet, he returns home to find the killer. To put the killer off guard he poses as a dude with a camera. Unknown to Click, the camera will reveal the killer's identity.
Cattle rancher John Drake sends his son, Ted, to the Mexican border to stop the smuggling that is using Drake's land as the crossing point. Ted meets Ysabel Castro, the daughter of the rancher just across the border-river, when he saves her from a mad-bull.
After he loses his money and horse in a poker game, Yak learns he was cheated. But then he learns that the men that cheated him are wanted and have a price on their heads. This gives him a chance to get his money back and more, so he sets out after them.
Yak arrives at the Gilmore ranch where rustling has occurred. Gilmore blames a wild horse when it is actually his foreman Mays. After Yak catches and tames the wild horse, Mays gets Yak out of the way by having him arrested for murder. Mays and his men can now make one last raid.
Carter Brace is out to murder Belden. Collins who was sent to bring in the border gang led by Brace, saves Belden's life in San Francisco. When they all reach the border, Brace tries again.
Tom Grant saves Grace Percival from being tromped by a herd of stampeding horses,led by Tony, and they become friends. Grace tells Slade, a renegade who has been trying to capture Tony, the leader of the wild horses, that Tom has promised to capture Tony for her. Not if Slade has anything to say about he isn't.
Robert Kane, owner of the Bar-L Ranch, has received word from his attorney that he will have to marry Ann Scott before the 15th of the month, whom he has never met, or else lose the title to the Vista Water Company, which Ann has inherited under the condition that she be married. There is dirty-work afoot, instigated by a lawyer.
Bradley Blatchford, returning to his father's ranch from college, meets Sybil Hamilton, who is coming to the ranch town as a schoolteacher. Later, Bradley's father is suspected of rustling cattle, but he denies the charge. As the romance develops between Bradley and Sybil, Bradley comes upon a rustler at work and is about to shoot when he discovers his own father, who claims he is victim of a hereditary taint that he cannot subdue. Some friends, who observe the incident, rustle some of Blatchford's cattle, mark it with Sybil's brand, and accuse her of rustling and hiding some dark secret. She confesses that her brother disgraced the family, and when George learns of it, he is forgiven and is reunited with her.
Lee Crush, an out-of-work cowhand, gets into a fight with Bull Dozier and knocks him through a railing. Thinking he has killed the man, Lee takes to his heels and finds work on the Shawn ranch. Lee prevents Clem Allen from swindling the Widow Shawn and falls in love with her daughter, Mary.
Railroad foreman Murray Sinclair is dismissed by George McCloud, division superintendent, for ransacking wrecks. Sinclair along with his henchmen, retire to his ranch and forays against the railroad. "Whispering Smith," engaged by the railroad to restore order, is hesitant in dealing with Sinclair when he falls in love with Marion, Sinclair's wife, who is separated from her husband and operates a small shop in Medicine Bend. Dicksie, McCloud's sweetheart, overhears Sinclair threaten McCloud, and she rides through a storm to warn him; Smith, with the aid of Bill Dancing, tracks down Sinclair and his men, and Bill kills the villain. Dicksie and McCloud marry and take Marion under their protection.
Blaze Burke, rough-and-ready lumberjack, is promised the job of camp boss if he eliminates a gang of lumber poachers. He is doublecrossed and the job goes to Milton Symmons, the employer's nephew.
Bill Miller, youngest member of the notorious Range Riders, gets job as pony express rider. Indians become dangerous on the war path. Bill forestalls plan of a bandit chief to rob mails while trying to win the love of a girl and the respect of "Uncle Sam."