In the lawless West, The Cowboys, a notorious brotherhood of killers and thieves, reigned over the land with brutal fists and fast guns. Fate had finally caught up with them and now the merciless gang has but a single surviving member. When a deputized gunslinger takes up the call to hunt down the last Cowboy, the chase is on and the bullets fly, and only one of these hardened men can survive.
A gang of cold-blooded outlaws narrowly escapes a blood-soaked bank robbery in a grimy frontier town. With a notorious bounty hunter hot on their trail, these nefarious criminals desperately need a place to hide out before night falls. Fate brings them to the home of the Tildons, a seemingly innocent family with two feisty daughters. As the men settle in, an impetuous game of cat and mouse plays out during the cold, black night. Come morning, nothing will ever be the same.
When the bank is robbed, Gene and the boys are singing nearby and the Chief arrests them as gang members but lets them go thinking they will lead them to the others.
Cholita, after a long absence in Mexico City, is returning home to take up her duties as head of the rancho and, as everyone expects, to marry her childhood sweetheart José. Expectations are somewhat dashed as she shows up with Fernando to whom she is engaged. This makes José and Cholita's uncle more than a little bit put out as Fernando is not only not a Mexican, he is also a city slicker afraid of the country.
El Chuncho's bandits rob arms from a train, intending to sell the weapons to Elias' revolutionaries. They are helped by one of the passengers, Bill Tate, and allow him to join them, unware of his true intentions.
Two men, an aging Native American and a ne'er-do-well trapper from North America, race to claim the stallion Eagle's Wing in antebellum Mexico, meeting marauded stagecoach travelers and garrisoned Mexicans along the way.
Arms dealer Yolaf Peterson aims to make a sale to guerilla Mongo, but the money is locked in a bank safe, the combination known only to Professor Xantos, a prisoner of the Americans. Yolaf agrees to free Xantos, accompanied by reluctant guerilla Basco, but a former business partner of Yolaf's- John 'The Wooden Hand', has other ideas.
Old Mexican-American sheriff Bob Valdez has always been a haven of sanity in a land of madmen when it came to defending law and order. But the weapon smuggler Frank Tanner is greedy and impulsive. When Tanner provokes a shooting that causes the death of an innocent man and Valdez asks him to financially compensate the widow, Tanner refuses to do so and severely humiliates Valdez, who will do justice and avenge his honor, no matter what it takes.
Seeking a new place to call home, former Confederate soldier Ben Lassiter (Victor Mature) and his daughter meet Beth (Elaine Stewart), whose fiancé is a Union soldier. Lassiter falls for Beth, and when Indians attack, they head to a cavalry camp where Lassiter must battle the Indians as well as Beth's fiancé.
A group of women contracted a strange fever and a former sheriff is responsible for taking them to the hospital in the nearest town, but in their way they will encounter a gang of murderers. His only hope is a woman whose beauty is matched only by his skill with weapons.
A young Abigale Archer is left friendless and alone in a brutal Montana winter during the 1870s—fighting for survival and to retrieve her one earthly possession, her family’s horse, from a gang of bloodthirsty bandits.
Heading through Colorado Territory in search of gold and women, Alferd Packer and his group of bemused companions find themselves lost, starving and musically inspired by the obstacles they confront along the way, including a die-hard Confederate cyclops, a trio of surly trappers, a tribe of Japanese-speaking "Indians," and ultimately, each other.
Roy runs away from the labor camp of Santa Lucia with Emiliano, a New Mexico rancher, both imprisoned unjustly for three powerful American bankers, to seize the gold mine that had Emiliano. During flight, the landowner dies and in his last moments asked Roy to recover the mine and save Jessica, daughter of his former foreman.
Amidst apocalyptic darkness and endless war, a young couple's mundane relationship is threatened by the arrival of a mysterious widow and a supernatural force that lurks in the forest around their cabin.
In Bolivia, Butch Cassidy (now calling himself James Blackthorn) pines for one last sight of home, an adventure that aligns him with a young robber and makes the duo a target for gangs and lawmen alike.